Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300, Bandar Puncak Alam, Malaysia.
Non-Destructive Biomedical and Pharmaceutical Research Centre, iPROMISE, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300, Bandar Puncak Alam, Malaysia.
AAPS PharmSciTech. 2019 Apr 15;20(5):164. doi: 10.1208/s12249-019-1362-7.
This review highlights in vitro drug dissolution/permeation methods available for topical and transdermal nanocarriers that have been designed to modulate the propensity of drug release, drug penetration into skin, and permeation into systemic circulation. Presently, a few of USFDA-approved in vitro dissolution/permeation methods are available for skin product testing with no specific application to nanocarriers. Researchers are largely utilizing the in-house dissolution/permeation testing methods of nanocarriers. These drug release and permeation methods are pending to be standardized. Their biorelevance with reference to in vivo plasma concentration-time profiles requires further exploration to enable translation of in vitro data for in vivo or clinical performance prediction.
本文综述了用于调节药物释放、药物渗透进入皮肤以及渗透进入体循环倾向的局部和透皮纳米载体的体外药物溶解/渗透方法。目前，有一些经美国 FDA 批准的适用于皮肤产品测试的体外溶解/渗透方法，但不适用于纳米载体。研究人员主要利用纳米载体的内部溶解/渗透测试方法。这些药物释放和渗透方法有待标准化。它们与体内血浆浓度-时间曲线的生物相关性需要进一步探索，以实现从体外数据向体内或临床性能预测的转化。
