小胶质细胞塑造社会行为的性别差异。
Microglia Sculpt Sex Differences in Social Behavior.
机构信息
Lurie Center for Autism, Massachusetts General Hospital for Children, Boston, MA 02114, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA.
Lurie Center for Autism, Massachusetts General Hospital for Children, Boston, MA 02114, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA.
出版信息
Neuron. 2019 Apr 17;102(2):275-277. doi: 10.1016/j.neuron.2019.03.039.
Microglia are increasingly recognized as developmental sculptors of neural circuits. In this issue of Neuron, VanRyzin et al. (2019) demonstrate a novel mechanism by which endocannabinoids drive microglia to phagocytose newborn astrocytes in the medial amygdala of male rats, promoting sex differences in social play behavior.
小胶质细胞越来越被认为是神经回路发育的塑造者。在本期《神经元》杂志上，VanRyzin 等人（2019 年）展示了一种新的机制，即内源性大麻素促使小胶质细胞吞噬雄性大鼠内侧杏仁核中的新生星形胶质细胞，从而促进了社会玩耍行为的性别差异。
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