Department of Medical and Population Health Research, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33178, USA.
Department of Public Health, Faculty of Medicine, University of Helsinki, 00100 Helsinki, Finland.
Int J Environ Res Public Health. 2019 Apr 18;16(8):1403. doi: 10.3390/ijerph16081403.
The objective of the demonstration project for type 2 diabetes prevention in the Barranquilla and Juan Mina (DEMOJUAN) study was to investigate the extent to which it is possible to reach normal glucose metabolism with early lifestyle interventions in people at high risk of type 2 diabetes (prediabetes), compared with those who receive standard usual care.
DEMOJUAN was a randomized controlled trial conducted in Juan Mina and Barranquilla, Northern Colombia. Eligible participants were randomized into one of three groups (control group, initial nutritional intervention, and initial physical activity intervention). The duration of the intervention was 24 months. The main study outcome in the present analysis was reversion to normoglycemia. Relative risks and their corresponding 95% confidence intervals were calculated for reversal to normoglycemia and T2D incidence.
There was no statistically significant association between the intervention groups and reversion to normoglycemia. The relative risk of reversion to normoglycemia was 0.88 (95% CI 0.70-1.12) for the initial nutritional intervention group participants and 0.95 (95% CI 0.75-1.20) for the initial physical activity intervention group participants.
Our study did not find any statistically significant differences in reversion to normoglycemia or the development of type 2 diabetes between the intervention groups and the control group in this population.
在 2 型糖尿病预防的巴兰基亚和胡安米纳（DEMOJUAN）研究中，示范项目的目的是研究通过早期生活方式干预，在 2 型糖尿病高危人群（糖尿病前期）中达到正常葡萄糖代谢的程度，与接受标准常规护理的人群相比。
DEMOJUAN 是在哥伦比亚北部的胡安米纳和巴兰基亚进行的一项随机对照试验。符合条件的参与者被随机分为三组（对照组、初始营养干预组和初始体力活动干预组）。干预的持续时间为 24 个月。本分析中的主要研究结果是恢复正常血糖水平。计算了恢复正常血糖和 T2D 发生率的逆转的相对风险及其相应的 95%置信区间。
干预组与恢复正常血糖之间没有统计学上的显著关联。初始营养干预组参与者恢复正常血糖的相对风险为 0.88（95%CI 0.70-1.12），初始体力活动干预组参与者为 0.95（95%CI 0.75-1.20）。
在该人群中，我们的研究未发现干预组与对照组在恢复正常血糖或 2 型糖尿病发展方面有任何统计学上的显著差异。
