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短阳离子拟肽抗菌剂。

Short Cationic Peptidomimetic Antimicrobials.

作者信息

Kuppusamy Rajesh, Willcox Mark, Black David StC, Kumar Naresh

机构信息

School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.

出版信息

Antibiotics (Basel). 2019 Apr 18;8(2):44. doi: 10.3390/antibiotics8020044.

DOI:10.3390/antibiotics8020044
PMID:31003540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6628222/
Abstract

The rapid growth of antimicrobial resistance against several frontline antibiotics has encouraged scientists worldwide to develop new alternatives with unique mechanisms of action. Antimicrobial peptides (AMPs) have attracted considerable interest due to their rapid killing and broad-spectrum activity. Peptidomimetics overcome some of the obstacles of AMPs such as high cost of synthesis, short half-life in vivo due to their susceptibility to proteolytic degradation, and issues with toxicity. This review will examine the development of short cationic peptidomimetics as antimicrobials.

摘要

针对几种一线抗生素的耐药性迅速增长，促使全球科学家研发具有独特作用机制的新替代物。抗菌肽（AMPs）因其快速杀菌和广谱活性而备受关注。拟肽克服了抗菌肽的一些障碍，如合成成本高、由于易受蛋白水解降解而在体内半衰期短以及毒性问题。本综述将探讨短阳离子拟肽作为抗菌剂的发展情况。

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