血清尿调蛋白与 1 型糖尿病青少年的主动脉僵硬度呈负相关：来自 EMERALD 研究的简要报告。
Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study.
机构信息
Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States.
Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, United States.
出版信息
J Diabetes Complications. 2019 Jun;33(6):434-436. doi: 10.1016/j.jdiacomp.2019.03.001. Epub 2019 Mar 21.
Abstract
Youth with type 1 diabetes (T1D) carry greater cardiovascular disease (CVD) risk than their nondiabetic peers. Low serum uromodulin (SUMOD) associates with increased CVD mortality in adults. We found that T1D youth have low SUMOD. Lower SUMOD correlated with aortic stiffness, suggesting its potential as a CVD biomarker in T1D.
摘要
1 型糖尿病（T1D）青少年的心血管疾病（CVD）风险高于非糖尿病同龄人。血清尿调蛋白（SUMOD）水平低与成年人 CVD 死亡率增加相关。我们发现 T1D 青少年的 SUMOD 水平较低。较低的 SUMOD 与主动脉僵硬度相关，提示其在 T1D 中作为 CVD 生物标志物的潜力。
相似文献
1
Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study.
J Diabetes Complications. 2019 Jun;33(6):434-436. doi: 10.1016/j.jdiacomp.2019.03.001. Epub 2019 Mar 21.
2
Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes.
J Diabetes Complications. 2019 Sep;33(9):648-650. doi: 10.1016/j.jdiacomp.2019.05.023. Epub 2019 Jun 3.
3
Association of serum uromodulin with mortality and cardiovascular disease in the elderly-the Cardiovascular Health Study.
Nephrol Dial Transplant. 2020 Aug 1;35(8):1399-1405. doi: 10.1093/ndt/gfz008.
4
Serum Uromodulin Predicts Less Coronary Artery Calcification and Diabetic Kidney Disease Over 12 Years in Adults With Type 1 Diabetes: The CACTI Study.
Diabetes Care. 2019 Feb;42(2):297-302. doi: 10.2337/dc18-1527. Epub 2018 Nov 27.
5
HbA1c but not diabetes duration predicts increased arterial stiffness in adolescents with poorly controlled type 1 diabetes.
Pediatr Diabetes. 2017 Jun;18(4):304-310. doi: 10.1111/pedi.12385. Epub 2016 Apr 14.
6
Association of Serum Uromodulin With ESKD and Kidney Function Decline in the Elderly: The Cardiovascular Health Study.
Am J Kidney Dis. 2019 Oct;74(4):501-509. doi: 10.1053/j.ajkd.2019.02.024. Epub 2019 May 22.
7
Arterial stiffness in adolescents and young adults with and without type 1 diabetes: the SEARCH CVD study.
Pediatr Diabetes. 2015 Aug;16(5):367-74. doi: 10.1111/pedi.12279. Epub 2015 Apr 24.
8
Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus.
Circulation. 2018 Dec 18;138(25):2895-2907. doi: 10.1161/CIRCULATIONAHA.118.035525.
9
The association of low-density lipoprotein cholesterol with elevated arterial stiffness in adolescents and young adults with type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth study.
Pediatr Diabetes. 2020 Aug;21(5):863-870. doi: 10.1111/pedi.13021. Epub 2020 May 5.
10
Serum uromodulin-a marker of kidney function and renal parenchymal integrity.
Nephrol Dial Transplant. 2018 Feb 1;33(2):284-295. doi: 10.1093/ndt/gfw422.
引用本文的文献
1
Serum and urinary uromodulin concentration in children and young adults with chronic kidney disease.
Pediatr Nephrol. 2025 May;40(5):1751-1758. doi: 10.1007/s00467-024-06630-z. Epub 2025 Jan 11.
2
Uromodulin biology.
Nephrol Dial Transplant. 2024 Jun 28;39(7):1073-1087. doi: 10.1093/ndt/gfae008.
3
Cardiovascular disease in young People with Type 1 Diabetes: Search for Cardiovascular Biomarkers.
J Diabetes Complications. 2020 Oct;34(10):107651. doi: 10.1016/j.jdiacomp.2020.107651. Epub 2020 Jun 6.
4
Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes.
J Diabetes Complications. 2019 Sep;33(9):648-650. doi: 10.1016/j.jdiacomp.2019.05.023. Epub 2019 Jun 3.
本文引用的文献
1
Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus.
Circulation. 2018 Dec 18;138(25):2895-2907. doi: 10.1161/CIRCULATIONAHA.118.035525.
2
Serum Uromodulin Predicts Less Coronary Artery Calcification and Diabetic Kidney Disease Over 12 Years in Adults With Type 1 Diabetes: The CACTI Study.
Diabetes Care. 2019 Feb;42(2):297-302. doi: 10.2337/dc18-1527. Epub 2018 Nov 27.
3
Impact of different coarctation therapies on aortic stiffness: phase-contrast MRI study.
Int J Cardiovasc Imaging. 2018 Sep;34(9):1459-1469. doi: 10.1007/s10554-018-1357-6. Epub 2018 Apr 17.
4
The value of uromodulin as a new serum marker to predict decline in renal function.
J Hypertens. 2018 Jan;36(1):110-118. doi: 10.1097/HJH.0000000000001527.
5
Uromodulin: from physiology to rare and complex kidney disorders.
Nat Rev Nephrol. 2017 Sep;13(9):525-544. doi: 10.1038/nrneph.2017.101. Epub 2017 Aug 7.
6
Serum Uromodulin and Mortality Risk in Patients Undergoing Coronary Angiography.
J Am Soc Nephrol. 2017 Jul;28(7):2201-2210. doi: 10.1681/ASN.2016111162. Epub 2017 Feb 27.
7
Serum uromodulin-a marker of kidney function and renal parenchymal integrity.
Nephrol Dial Transplant. 2018 Feb 1;33(2):284-295. doi: 10.1093/ndt/gfw422.
8
Serum uromodulin is a predictive biomarker for cardiovascular events and overall mortality in coronary patients.
Int J Cardiol. 2017 Mar 15;231:6-12. doi: 10.1016/j.ijcard.2016.12.183. Epub 2016 Dec 29.
9
Cardiovascular disease and type 1 diabetes: prevalence, prediction and management in an ageing population.
Ther Adv Chronic Dis. 2015 Nov;6(6):347-74. doi: 10.1177/2040622315598502.
10
Arterial stiffness in adolescents and young adults with and without type 1 diabetes: the SEARCH CVD study.
Pediatr Diabetes. 2015 Aug;16(5):367-74. doi: 10.1111/pedi.12279. Epub 2015 Apr 24.
Zotero 插件