妊娠期高血压：病理生理学与治疗
Hypertension in pregnancy: Pathophysiology and treatment.
作者信息
Braunthal Stephanie, Brateanu Andrei
机构信息
Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
出版信息
SAGE Open Med. 2019 Apr 10;7:2050312119843700. doi: 10.1177/2050312119843700. eCollection 2019.
Abstract
Hypertensive disorders of pregnancy, an umbrella term that includes preexisting and gestational hypertension, preeclampsia, and eclampsia, complicate up to 10% of pregnancies and represent a significant cause of maternal and perinatal morbidity and mortality. Despite the differences in guidelines, there appears to be consensus that severe hypertension and non-severe hypertension with evidence of end-organ damage need to be controlled; yet the ideal target ranges below 160/110 mmHg remain a source of debate. This review outlines the definition, pathophysiology, goals of therapy, and treatment agents used in hypertensive disorders of pregnancy.
摘要
妊娠高血压疾病是一个统称，包括孕前高血压和妊娠期高血压、子痫前期和子痫，高达10%的妊娠会并发该疾病，是孕产妇和围产儿发病和死亡的重要原因。尽管指南存在差异，但似乎有一个共识，即重度高血压以及有靶器官损害证据的非重度高血压需要得到控制；然而，低于160/110 mmHg的理想目标范围仍是一个争议点。本综述概述了妊娠高血压疾病的定义、病理生理学、治疗目标以及治疗药物。
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