Huang Qiang, Dong Kaikai, Bai Wenjing, Yi Dong, Ji Jian-Xin, Wei Wei
Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 , China.
University of Chinese Academy of Sciences , Beijing 100049 , China.
Org Lett. 2019 May 3;21(9):3332-3336. doi: 10.1021/acs.orglett.9b01081. Epub 2019 Apr 22.
A new TEMPO-catalyzed aminophosphinoylation of ethers with amines and H-phosphine oxides was developed for the synthesis of α-aminophosphine oxides. This metal-free aminophosphinoylation reaction could be conducted under mild conditions through tandem C(sp)-H and C(sp)-O bond cleavage. The present method offers a facile and efficient approach to broad range of α-aminophosphine oxide derivatives in moderate to good yields with excellent functional group tolerance.
开发了一种新的TEMPO催化的醚与胺和H-膦氧化物的氨基膦酰化反应,用于合成α-氨基膦氧化物。这种无金属的氨基膦酰化反应可以在温和条件下通过串联C(sp)-H和C(sp)-O键断裂进行。该方法为广泛的α-氨基膦氧化物衍生物提供了一种简便有效的方法,产率适中至良好,官能团耐受性优异。