蠕虫产物直接调节介导实验性自身免疫性脑脊髓炎的 T 细胞。
Helminths products directly modulate T cells that mediate experimental autoimmune encephalomyelitis.
机构信息
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
出版信息
Eur J Immunol. 2019 Aug;49(8):1291-1294. doi: 10.1002/eji.201948147. Epub 2019 May 2.
PMID:31016721
Abstract
Infection with helminths can protect against the development of autoimmune diseases and this has been associated with induction of anti-inflammatory innate immune responses and Tregs. Here, we demonstrate that helminth-derived products can directly target T cells, especially IL-17-secreting γδ T cells that play a key pathogenic role in CNS autoimmune disease.
摘要
寄生虫感染可以预防自身免疫性疾病的发生，这与诱导抗炎先天免疫反应和 Treg 有关。在这里，我们证明寄生虫衍生产物可以直接靶向 T 细胞，特别是在中枢神经系统自身免疫性疾病中发挥关键致病作用的分泌白介素-17 的 γδ T 细胞。
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