用于不对称联芳基合成的化学选择性硼-卡斯特拉尼芳基化反应
Chemoselective Borono-Catellani Arylation for Unsymmetrical Biaryls Synthesis.
作者信息
Wang Peng, Chen Shuqing, Zhou Zhiyu, Cheng Hong-Gang, Zhou Qianghui
机构信息
Sauvage Center for Molecular Sciences, College of Chemistry and Molecular Sciences , Wuhan University , 430072 Wuhan , China.
Institute for Advanced Studies , Wuhan University , 430072 Wuhan , China.
出版信息
Org Lett. 2019 May 3;21(9):3323-3327. doi: 10.1021/acs.orglett.9b01072. Epub 2019 Apr 24.
Reported is the borono-Catellani arylation process for unsymmetrical biaryls synthesis, utilizing the readily available pinacol ester of arylboronic acids, aryl bromides, and olefins as the reactants. The distinct reactivity of arylboronic ester and aryl bromides secures the excellent chemoselectivity in the pivotal arylation step. The reaction is enabled by the cooperative catalysis of Pd(OAc) and the NBE derivative N, with molecular oxygen as the terminal oxidant.
报道了一种用于不对称联芳基合成的硼基-卡斯特拉尼芳基化反应，该反应利用易于获得的芳基硼酸频哪醇酯、芳基溴化物和烯烃作为反应物。芳基硼酸酯和芳基溴化物的独特反应活性确保了关键芳基化步骤中出色的化学选择性。该反应由Pd(OAc)和NBE衍生物N协同催化，以分子氧作为终端氧化剂。
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