Al-Yasiri Amal Y, White Nathan E, Katti Kattesh V, Loyalka Sudarshan K
Nuclear Science and Engineering Institute, University of Missouri, Columbia, MO, USA.
Department of Basic Sciences, College of Dentistry, University of Baghdad, Bab Al-Muadham, Baghdad, Iraq.
Rep Pract Oncol Radiother. 2019 May-Jun;24(3):288-293. doi: 10.1016/j.rpor.2019.02.006. Epub 2019 Apr 9.
The objective of this research was to estimate the dose distribution delivered by radioactive gold nanoparticles (AuNPs or AuNPs) to the tumor inside the human prostate as well as to normal tissues surrounding the tumor using the Monte-Carlo N-Particle code (MCNP-6.1.1 code).
Radioactive gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated to treat prostate cancer in animals. In order to use them as a new therapeutic modality to treat human prostate cancer, accurate radiation dosimetry simulations are required to estimate the energy deposition in the tumor and surrounding tissue and to establish the course of therapy for the patient.
A simple geometrical model of a human prostate was used, and the dose deposited by AuNPs or AuNPs to the tumor within the prostate as well as to the healthy tissue surrounding the prostate was calculated using the MCNP code. Water and A-150 TEP phantoms were used to simulate the soft and tumor tissues.
The results showed that the dose due to AuNPs or AuNPs, which are distributed homogenously in the tumor, had a maximal value in the tumor region and then rapidly decreased toward the prostate-tumor interface and surrounding organs. However, the dose deposited by Au is significantly higher than the dose deposited by Au in the tumor region as well as normal tissues.
According to the MCNP results, AuNPs are a promising modality to treat prostate cancer and other cancers and AuNPs could be used for imaging purposes.
本研究的目的是使用蒙特卡罗N粒子代码（MCNP - 6.1.1代码）估算放射性金纳米颗粒（AuNPs）递送至人前列腺内肿瘤以及肿瘤周围正常组织的剂量分布。
放射性金纳米颗粒正成为有前景的癌症治疗剂，并且正在进行动物前列腺癌治疗的研究。为了将它们用作治疗人类前列腺癌的新治疗方式，需要精确的辐射剂量学模拟来估算肿瘤和周围组织中的能量沉积，并为患者确定治疗方案。
使用了一个简单的人前列腺几何模型，并用MCNP代码计算了AuNPs递送至前列腺内肿瘤以及前列腺周围健康组织的剂量。用水和A - 150 TEP体模来模拟软组织和肿瘤组织。
结果表明，在肿瘤中均匀分布的AuNPs所产生的剂量在肿瘤区域有最大值，然后朝着前列腺 - 肿瘤界面和周围器官迅速降低。然而，在肿瘤区域以及正常组织中，Au沉积 的剂量明显高于Au沉积的剂量。
根据MCNP结果，AuNPs是治疗前列腺癌和其他癌症的一种有前景的方式，并且AuNPs可用于成像目的。
