慢性复发性多灶性骨髓炎——两例患者的病例报告及文献综述
Chronic recurrent multifocal osteomyelitis-case report of two patients and review of literature.
作者信息
Schwarzkopf Eugenia, Agaram Narasimhan P, Ha Spencer, Prince Daniel E
机构信息
Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.
Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
出版信息
Int J Clin Rheumtol. 2019;14(1):24-30. doi: 10.4172/1758-4272.1000220.
BACKGROUND
Chronic Recurrent Multifocal Osteomyelitis (CRMO) is an autoinflammatory skeletal disease characterized by unifocal or multifocal nonbacterial inflammatory bone lesions in the metaphysis of long bones. Common sites of CRMO are tibia, pelvis, proximal femur, clavicle, calcaneum and vertebrae. However, unifocal presentation or presentation in adults, atypical locations, and absence of recurrence have also been reported.
METHODS AND FINDINGS
We describe two cases of female patients with unifocal presentation of nonbacterial inflammatory bone lesions in the upper and lower extremity. Furthermore, a review of literature is presented.
CONCLUSION
Although CRMO is seen primarily in children and adolescents, and usually occurs in a multifocal pattern, our cases illustrate that this disease can arise in adult patients and in a single location. The diagnosis of CRMO should be made in a multi-disciplinary approach amongst orthopedic surgeons, radiologists and pathologists.
背景
慢性复发性多灶性骨髓炎（CRMO）是一种自身炎症性骨骼疾病，其特征为长骨干骺端出现单灶性或多灶性非细菌性炎性骨病变。CRMO的常见部位包括胫骨、骨盆、股骨近端、锁骨、跟骨和椎骨。然而，也有单灶性表现或成人发病、非典型部位以及无复发的报道。
方法与结果
我们描述了两例女性患者，其上下肢出现单灶性非细菌性炎性骨病变。此外，还对文献进行了综述。
结论
尽管CRMO主要见于儿童和青少年，且通常呈多灶性发病，但我们的病例表明，这种疾病也可发生于成年患者且为单灶性。CRMO的诊断应通过骨科医生、放射科医生和病理学家的多学科方法进行。
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