Cartoon Jodi, Ramalingam Jothi
Psychiatry Registrar, Consultation Liaison Psychiatry Department, Gosford Hospital, Gosford, NSW, Australia.
Consultant Psychiatrist, Consultation Liaison Psychiatry Department, Gosford Hospital, Gosford, NSW, Australia.
Australas Psychiatry. 2019 Oct;27(5):456-461. doi: 10.1177/1039856219839476. Epub 2019 Apr 29.
To explore the presence of dopamine dysregulation syndrome in non-Parkinson's disease patients receiving dopamine replacement therapy.
Electronic searches were conducted of Medline, Embase, PsycINFO and PreMedline to capture articles related to dopamine misuse or factitious disorder combined with the presence of dopamine replacement therapy or a non-Parkinson's disease population. In total, 430 articles were reviewed and studies that addressed dopamine dysregulation syndrome in non-Parkinson's disease patients were included.
Nine case reports were identified.
The pathophysiology underlying dopamine dysregulation syndrome has been thoroughly explored with numerous mechanisms posited. What remains unclear is whether dopamine dysregulation syndrome is a phenomenon specific to Parkinson's disease, as indicated in the proposed diagnostic criteria. A more useful predictor of susceptibility to dopamine dysregulation syndrome may be temperamental traits such as novelty seeking and impulsivity, which overlap with predisposing factors for an addiction disorder.
探讨接受多巴胺替代疗法的非帕金森病患者中多巴胺调节障碍综合征的存在情况。
对Medline、Embase、PsycINFO和PreMedline进行电子检索，以获取与多巴胺滥用或做作性障碍以及多巴胺替代疗法的存在或非帕金森病患者群体相关的文章。总共审查了430篇文章，并纳入了涉及非帕金森病患者多巴胺调节障碍综合征的研究。
确定了9例病例报告。
多巴胺调节障碍综合征的潜在病理生理学已通过多种提出的机制进行了深入探讨。尚不清楚的是，如拟议的诊断标准所示，多巴胺调节障碍综合征是否是帕金森病特有的现象。对多巴胺调节障碍综合征易感性的一个更有用的预测指标可能是诸如寻求新奇和冲动等气质特征，这些特征与成瘾性障碍的易感因素重叠。
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