通过协同抑制 DNA 损伤反应和免疫检查点通路，对小细胞肺癌实施 STING 打击。
Delivering a STINGing Blow to Small Cell Lung Cancer via Synergistic Inhibition of DNA-Damage Response and Immune-Checkpoint Pathways.
机构信息
Fred Hutchinson Cancer Research Center, Seattle, Washington.
出版信息
Cancer Discov. 2019 May;9(5):584-586. doi: 10.1158/2159-8290.CD-19-0234.
PMID:31043412
Abstract
Small cell lung cancer (SCLC) has demonstrated modest responses to immune-checkpoint blockade despite harboring a high mutational burden. In this issue, Sen and colleagues show remarkable synergy between inhibition of the DNA-damage response and the PD-1 axis, resulting in striking tumor regressions in SCLC mouse models..
摘要
小细胞肺癌 (SCLC) 尽管具有较高的突变负担，但对免疫检查点阻断的反应仅为适度。在本期杂志中，Sen 及其同事表明，DNA 损伤反应抑制与 PD-1 轴之间存在显著的协同作用，导致 SCLC 小鼠模型中的肿瘤明显消退。
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