Neurosurgery Clinic, "Prof. Dr. N. Oblu" Emergency Clinical Hospital, Iasi, Romania.
Department of Ophthalmology, "Grigore. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
World Neurosurg. 2019 Aug;128:37-46. doi: 10.1016/j.wneu.2019.04.199. Epub 2019 Apr 29.
Intracranial meningiomas are brain tumors that have probably been known the longest, largely because of the occasional production of grotesque cranial deformities that have attracted the attention and interest of humankind. Because of the tendency of some intracranial meningiomas to cause skull deformation and thickening, these tumors have given rise to various speculations and theories related to their origin, starting in prehistoric times up to the present.
From the Steinheim skull and "pharaonic meningiomas" to the first meningioma monograph and the first explanations of Harvey Cushing regarding the mechanism of hyperostosis, this review aims to weave again the story of Arachne. We identify the main contributors who have tried to understand and explain the tendency of some of these tumors to cause hyperostosis or other skull bone involvements.
The contribution of neurosurgeons or pathologists over the centuries is of undeniable importance and is the basis for understanding future molecular mechanisms.
颅内脑膜瘤是人类最早认识的脑肿瘤之一，这主要是因为偶尔会出现怪异的颅骨畸形，这些畸形引起了人类的关注和兴趣。由于一些颅内脑膜瘤有引起颅骨变形和增厚的倾向，这些肿瘤引发了各种关于其起源的推测和理论，从史前时期一直到现在。
从斯坦海姆颅骨和“法老脑膜瘤”到第一本脑膜瘤专着和 Harvey Cushing 关于骨质增生机制的第一个解释，本综述旨在再次编织阿拉克涅的故事。我们确定了主要的贡献者，他们试图理解和解释这些肿瘤中的一些引起骨质增生或其他颅骨受累的倾向。
几个世纪以来神经外科医生或病理学家的贡献是不可否认的重要，并且是理解未来分子机制的基础。
