Role of MFHAS1 in regulating hepcidin expression via the BMP/SMAD and MAPK/ERK1/2 signalling pathways.
作者信息
Kumkhaek Chutima, LaChance Christian, Aerbajinai Wulin, Zhu Jianqiong, Rodgers Griffin P
机构信息
Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
出版信息
Br J Haematol. 2019 Aug;186(4):e108-e112. doi: 10.1111/bjh.15939. Epub 2019 May 2.
Abstract
摘要
相似文献
1
Role of MFHAS1 in regulating hepcidin expression via the BMP/SMAD and MAPK/ERK1/2 signalling pathways.
Br J Haematol. 2019 Aug;186(4):e108-e112. doi: 10.1111/bjh.15939. Epub 2019 May 2.
2
Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin.
Sci Rep. 2015 Sep 11;5:13986. doi: 10.1038/srep13986.
3
Hepcidin and the BMP-SMAD pathway: An unexpected liaison.
Vitam Horm. 2019;110:71-99. doi: 10.1016/bs.vh.2019.01.004. Epub 2019 Feb 10.
4
Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice.
Blood. 2016 May 12;127(19):2327-36. doi: 10.1182/blood-2015-11-681494. Epub 2016 Jan 11.
5
GDF11 contributes to hepatic hepcidin (HAMP) inhibition through SMURF1-mediated BMP-SMAD signalling suppression.
Br J Haematol. 2020 Jan;188(2):321-331. doi: 10.1111/bjh.16156. Epub 2019 Aug 16.
6
Gain-of-function mutations in PIEZO1 directly impair hepatic iron metabolism via the inhibition of the BMP/SMADs pathway.
Am J Hematol. 2020 Feb;95(2):188-197. doi: 10.1002/ajh.25683. Epub 2019 Dec 9.
7
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD.
J Mol Med (Berl). 2009 May;87(5):471-80. doi: 10.1007/s00109-009-0447-2. Epub 2009 Feb 20.
8
Bone morphogenetic protein-binding endothelial regulator of liver sinusoidal endothelial cells induces iron overload in a fatty liver mouse model.
J Gastroenterol. 2017 Mar;52(3):341-351. doi: 10.1007/s00535-016-1237-6. Epub 2016 Jun 30.
9
Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling.
Blood. 2012 Mar 29;119(13):3187-9. doi: 10.1182/blood-2012-01-405563.
10
Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation.
Haematologica. 2016 Mar;101(3):297-308. doi: 10.3324/haematol.2015.127902. Epub 2015 Dec 3.
引用本文的文献
1
The BMP Signaling Pathway: Bridging Maternal-Fetal Crosstalk in Early Pregnancy.
Reprod Sci. 2025 May;32(5):1427-1445. doi: 10.1007/s43032-024-01777-4. Epub 2025 Jan 16.
本文引用的文献
1
Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways.
Cell Death Dis. 2017 May 4;8(5):e2763. doi: 10.1038/cddis.2017.102.
2
HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia.
Nature. 2014 Oct 9;514(7521):242-6. doi: 10.1038/nature13614. Epub 2014 Aug 24.
3
MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway.
Blood. 2013 Apr 18;121(16):3216-27. doi: 10.1182/blood-2011-10-385252. Epub 2013 Jan 17.
4
Identification and characterization of novel full-length cDNAs expressed during hematopoietic lineage-specific differentiation of cultured human peripheral blood mononuclear cells.
Blood Cells Mol Dis. 2013 Mar;50(3):154-5. doi: 10.1016/j.bcmd.2012.12.001. Epub 2012 Dec 23.
5
Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1(Suppl 1):4631-8. doi: 10.1073/pnas.1000093107. Epub 2010 Jun 29.
6
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
Nature. 2007 Jan 4;445(7123):102-5. doi: 10.1038/nature05378. Epub 2006 Dec 10.
7
Regulation of iron metabolism by hepcidin.
Annu Rev Nutr. 2006;26:323-42. doi: 10.1146/annurev.nutr.26.061505.111303.
8
Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells.
FEBS Lett. 2005 Dec 19;579(30):6716-20. doi: 10.1016/j.febslet.2005.10.067. Epub 2005 Nov 21.
9
10
Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1.
Nature. 1997 Oct 9;389(6651):618-22. doi: 10.1038/39348.
Zotero 插件