Barrett P A, Butler K D, Shand R A, Wallis R B
Thromb Haemost. 1986 Dec 15;56(3):311-7.
Intravenous administration of arachidonic acid to guinea-pigs caused a dose-related, rapid accumulation of 51Cr-labelled platelets in the thorax. Inhibitors of cyclooxygenase inhibited the platelet accumulation, induced by arachidonic acid (30 mg/kg), at doses which did not alter the thoracic blood volume (as measured by 131I-labelled human albumin). Thromboxane synthetase inhibitors had different effects on platelet accumulation depending on the dose. CGS 12970 (3 mg/kg) and N(1-carboxyheptyl) imidazole (100 mg/kg) reduced platelet accumulation. High doses of CGS 12970 and CGS 13080 caused an apparent enhancement of platelet accumulation which was associated with pooling of blood in the thorax, as measured by either 131I-labelled human albumin or 51Cr-labelled erythrocytes. This increase in thoracic blood volume was abolished if the guinea-pigs were also pretreated with diclofenac (1 mg/kg) in addition to the thromboxane synthetase inhibitor. Increases in thoracic blood volume were also obtained following infusions of PGI2 but not PGD2 or PGE2.
给豚鼠静脉注射花生四烯酸会导致胸部51Cr标记的血小板呈剂量相关的快速积聚。环氧合酶抑制剂在不改变胸血容量（通过131I标记的人白蛋白测量）的剂量下，抑制了由花生四烯酸（30mg/kg）诱导的血小板积聚。血栓素合成酶抑制剂对血小板积聚的影响因剂量而异。CGS 12970（3mg/kg）和N（1-羧基庚基）咪唑（100mg/kg）减少了血小板积聚。高剂量的CGS 12970和CGS 13080导致血小板积聚明显增强，这与通过131I标记的人白蛋白或51Cr标记的红细胞测量的胸部血液淤积有关。如果豚鼠除了接受血栓素合成酶抑制剂外还预先用双氯芬酸（1mg/kg）处理，则胸血容量的这种增加会被消除。输注前列环素后也会出现胸血容量增加，但输注前列腺素D2或前列腺素E2后则不会。
