DiMaggio Paul J, Kutler David I, Cohen Marc A, Chen Zhengming, Hoda Rana S
Department of Pathology and Laboratory Medicine, Papanicolaou Cytopathology Laboratory, New York Presbyterian Hospital-Weill Cornell Medical College, 525 East 68th Street, New York, New York.
Department of Otolaryngology, New York Presbyterian Hospital-Weill Cornell Medical College, New York, New York.
J Am Soc Cytopathol. 2015 Nov-Dec;4(6):313-320. doi: 10.1016/j.jasc.2015.06.003. Epub 2015 Jun 19.
Ultrasonography-guided fine-needle aspiration (US-FNA) yields diagnostic material more often than palpation-guided FNA does. It is often performed by an interventional radiologist (IR) but rarely by a cytopathologist (CP). Herein we describe our method of performance and growing experience with this technique.
Data from US-FNA of head and neck lesions performed over a 33-month period by both a CP and an IR were reviewed. Special attention was paid to cases for which histologic follow-up was available. Association in concordance between cytologic and histologic diagnoses was attempted using Fisher's exact test. Mean size of masses biopsied, number of passes performed, and passes needed to achieve adequacy were compared between groups using the Wilcoxon rank-sum test. Tests were 2-sided with P < 0.05 regarded as statistically significant.
Of the 175 US-FNAs performed, 108 (62%) were done by the CP and 67 (38%) by the IR. Fifty-eight patients had histologic follow-up; 37 (64%) for the CP and 21 (36%) for the IR. Mean mass size was significantly smaller for the IR at 2.11 cm versus 2.9 cm for the CP (P = 0.021). Adequacy was achieved after 1 pass in 70% of cases (26 of 37) by the CP and 67% (14 of 21) by the IR. Number of passes performed did not vary significantly between groups. A variety of masses were biopsied; however, the small sample size precluded meaningful evaluation of cytologic concordance to final histology.
CP-performed US-FNA has been successfully delivered to clinicians at our institution.
超声引导下细针穿刺抽吸术(US-FNA)获取诊断材料的成功率高于触诊引导下的细针穿刺抽吸术。该操作通常由介入放射科医生(IR)进行,但很少由细胞病理学家(CP)实施。在此,我们描述了我们的操作方法以及在这项技术方面不断积累的经验。
回顾了由细胞病理学家和介入放射科医生在33个月期间对头颈部病变进行US-FNA的数据。特别关注有组织学随访结果的病例。尝试使用Fisher精确检验来分析细胞学诊断与组织学诊断之间的一致性。使用Wilcoxon秩和检验比较两组活检肿块的平均大小、穿刺次数以及获得足够样本所需的穿刺次数。检验为双侧检验,P < 0.05被视为具有统计学意义。
在175例US-FNA操作中,细胞病理学家完成了108例(62%),介入放射科医生完成了67例(38%)。58例患者有组织学随访结果;细胞病理学家组有37例(64%),介入放射科医生组有21例(36%)。介入放射科医生活检的肿块平均大小明显较小,为2.11厘米,而细胞病理学家活检的肿块平均大小为2.9厘米(P = 0.021)。细胞病理学家组70%(37例中的26例)和介入放射科医生组67%(21例中的14例)的病例在1次穿刺后获得了足够样本。两组的穿刺次数没有显著差异。活检了多种肿块;然而,样本量较小,无法对细胞学诊断与最终组织学诊断的一致性进行有意义的评估。
在我们机构,细胞病理学家实施的US-FNA已成功应用于临床医生。