Department of Urology and Pediatric Urology, Julius-Maximilians-University of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
World J Urol. 2020 Feb;38(2):315-321. doi: 10.1007/s00345-019-02792-w. Epub 2019 May 3.
The aim of this study is to review the current literature that reports outcomes of Peyronie's disease (PD) reconstructive surgery using the collagen fleece TachoSil (Baxter, CA, USA), a novel graft that has self-adhesive properties and gained popularity in recent years.
A literature review was performed through PubMed between 2013 and 2018 regarding the use of TachoSil in PD penile reconstructive surgery. Keywords used for the search were: Peyronie's disease, surgical therapy, surgical outcomes, grafting techniques, graft materials, collagen fleece, surgical patch, and TachoSil.
Grafting procedures are indicated for men with PD and preserved erectile function. TachoSil is a novel graft used for defect closure after tunical incision or partial plaque excision. Long-term results of this technique are encouraging and reliable. One major advantage over other grafts is that the TachoSil does not require suture fixation leading to significantly decreased operative times. Another indication is residual curvature correction by plaque incision and grafting/sealing with TachoSil during penile prosthesis implantation in patients with PD and severe erectile dysfunction. Besides reduced operative times, the major advantage is that there is no risk of device puncture because of the self-adhesive properties of the TachoSil.
The TachoSil has emerged as a safe, reliable, and promising graft in PD reconstructive surgery. Until now, this graft has met the expectations as a durable and effective graft, not only for grafting techniques but also for residual curvature correction during penile prosthesis implantation. However, future research is encouraged, preferably within prospective multicenter studies.
本研究旨在回顾目前关于使用 TachoSil（Baxter，CA，美国）治疗 Peyronie 病（PD）重建手术的文献，这是一种新型移植物，具有自粘性，近年来越来越受欢迎。
通过 2013 年至 2018 年在 PubMed 上对 TachoSil 在 PD 阴茎重建手术中的应用进行文献复习。用于搜索的关键词是：Peyronie 病、手术治疗、手术结果、移植技术、移植材料、胶原毡、手术补丁和 TachoSil。
移植手术适用于 PD 且保留勃起功能的患者。TachoSil 是一种新型移植物，用于修复筋膜切开或部分斑块切除后的缺损。该技术的长期结果令人鼓舞且可靠。与其他移植物相比，其主要优势之一是 TachoSil 不需要缝合固定，从而显著缩短了手术时间。另一个适应证是 PD 伴严重勃起功能障碍患者在植入阴茎假体时通过斑块切开和用 TachoSil 移植/密封来矫正残余弯曲。除了缩短手术时间外，主要优点是由于 TachoSil 具有自粘性，因此不存在器械刺穿的风险。
TachoSil 已成为 PD 重建手术中一种安全、可靠、有前途的移植物。到目前为止，这种移植物不仅在移植技术方面，而且在阴茎假体植入时矫正残余弯曲方面，都满足了持久有效的移植物的期望。然而，鼓励开展未来的研究，最好是在前瞻性多中心研究中进行。
