Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, 20993, USA.
Cancer Metastasis Rev. 2019 Jun;38(1-2):297-305. doi: 10.1007/s10555-019-09795-4.
The presence of circulating tumor cells (CTCs) in the bloodstream signals the existence of a tumor and denotes risk of metastatic spread. CTCs can be isolated and analyzed to monitor cancer progression and therapeutic response. However, CTC isolation devices have shown considerable variation in detection rates, limiting their use as a routine diagnostic and monitoring tool. In this review, we discuss recent advances in CTC detection methodologies and associated clinical studies. We provide perspective on the future direction of CTC isolation and molecular characterization towards developing reliable biomarkers that monitor disease progression or therapeutic response.
循环肿瘤细胞（CTCs）在血液中的存在表明肿瘤的存在，并预示着转移扩散的风险。可以对 CTC 进行分离和分析，以监测癌症的进展和治疗反应。然而，CTC 分离设备在检测率方面存在很大差异，限制了其作为常规诊断和监测工具的使用。在这篇综述中，我们讨论了 CTC 检测方法的最新进展以及相关的临床研究。我们对 CTC 分离和分子特征分析的未来方向提出了看法，以期开发出可靠的生物标志物来监测疾病的进展或治疗反应。
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