药物使用对儿科重症监护病房液体超负荷的影响：一项前瞻性观察研究。
Medication Use as a Contributor to Fluid Overload in the PICU: A Prospective Observational Study.
作者信息
Fuhrman Dana, Crowley Kelli, Vetterly Carol, Hoshitsuki Keito, Koval Alaina, Carcillo Joseph
机构信息
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.
出版信息
J Pediatr Intensive Care. 2018 Jun;7(2):69-74. doi: 10.1055/s-0037-1604422. Epub 2017 Jul 26.
Abstract
In this prospective observational study, we explored the association of daily fluid intake from medication use with fluid overload in 75 children beginning 24 hours after intubation. The mean percent daily fluid intake from medications was 29% in the overall cohort. Excess intake and inadequate output contributed significantly to fluid overload. In the 28 patients who became ≥10% fluid overloaded, the mean percent daily fluid intake from medications was 34%, but just 23% in the patients who did not. Awareness of volume contribution and maximized concentration of parenteral medications when able may lessen the burden of fluid overload.
摘要
在这项前瞻性观察研究中，我们探讨了75名儿童在插管后24小时开始使用药物的每日液体摄入量与液体超负荷之间的关联。在整个队列中，药物每日液体摄入量的平均百分比为29%。摄入过多和输出不足是导致液体超负荷的重要因素。在28名液体超负荷≥10%的患者中，药物每日液体摄入量的平均百分比为34%，而未出现液体超负荷的患者中这一比例仅为23%。意识到容量贡献并尽可能提高肠外药物的浓度可能会减轻液体超负荷的负担。
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