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肺动脉瘤:术前、术中和术后的发现。

Pulmonary artery aneurysms: Preoperative, intraoperative, and postoperative findings.

作者信息

Worku Berhane M, de Angelis Paolo, Wingo Matthew E, Leonard Jeremy R, Khan Faiza M, Hameed Irbaz, Ruan Yongle, Gaudino Mario F L, Girardi Leonard N

机构信息

Department of Cardiothoracic Surgery, Weil Cornell Medicine, New York, New York.

出版信息

J Card Surg. 2019 Jul;34(7):570-576. doi: 10.1111/jocs.14070. Epub 2019 May 15.

Abstract

BACKGROUND

Pulmonary artery aneurysms (PAAs) are a rare but potentially lethal cardiovascular pathology. PAAs tend to develop in young patients with no gender discrepancy; they are most often associated with congenital heart disorders but also with systemic infections, vasculitis, pulmonary arterial hypertension, chronic pulmonary embolism, and malignancies. Dissection and rupture carry significant morbidity and mortality, thus patients require careful management, especially those with associated pulmonary hypertension. Given the rarity of this condition, physicians have yet to establish standard treatment guidelines. Most studies published to date are case reports with one or two patients; here, we describe our experience with six cases of large PAAs treated surgically at our institution.

METHODS

We identified and retrospectively analyzed clinical data for patients who underwent surgery for PAAs between 2009 and 2017.

RESULTS

The average age at surgery was 59.73 years, five patients were females, and 83.3% had baseline hypertension. Systolic murmurs were the most common clinical finding. The average aneurysmal size was 65.0 mm. We repaired the PAA with a woven Dacron graft (22-26 mm) in four patients. We performed concomitant pulmonary valve procedures on five patients: four replacements and one repair. Mean pump and cross-clamp times were 108.5 and 65 minutes. Operative and 30-day mortality was 0%. Average length of stay was 10.5 days.

CONCLUSIONS

Postoperative mortality was 0%; all patients showed improvement of symptoms after surgery. These findings confirm that PAA repair has an acceptable risk profile in select patients.

摘要

背景

肺动脉瘤(PAA)是一种罕见但可能致命的心血管疾病。PAA往往在年轻患者中发生,无性别差异;最常与先天性心脏病相关,但也与全身感染、血管炎、肺动脉高压、慢性肺栓塞和恶性肿瘤有关。夹层和破裂会带来显著的发病率和死亡率,因此患者需要仔细管理,尤其是那些伴有肺动脉高压的患者。鉴于这种疾病的罕见性,医生尚未建立标准的治疗指南。迄今为止发表的大多数研究都是一两名患者的病例报告;在此,我们描述了我们机构手术治疗6例大型PAA的经验。

方法

我们确定并回顾性分析了2009年至2017年间接受PAA手术患者的临床数据。

结果

手术时的平均年龄为59.73岁,5例患者为女性,83.3%有基线高血压。收缩期杂音是最常见的临床发现。动脉瘤平均大小为65.0毫米。我们用编织涤纶补片(22 - 26毫米)修复了4例患者的PAA。我们对5例患者进行了同期肺动脉瓣手术:4例置换和1例修复。平均体外循环时间和主动脉阻断时间分别为108.5分钟和65分钟。手术死亡率和30天死亡率均为0%。平均住院时间为10.5天。

结论

术后死亡率为0%;所有患者术后症状均有改善。这些发现证实,在特定患者中,PAA修复具有可接受的风险状况。

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