[衰老对人动脉内皮依赖性血管舒张功能的影响]
[Effects of Aging on Endothelium-dependent Vasodilation of Human Artery].
作者信息
Li Qi-Yong, Zhu Min-Jia, Chen Li
机构信息
Department of Cardiology, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, Chengdu 610072, China.
Department of Physiology, West China School of Basic Medicine and Forensic Medicine, Sichuan University, Chengdu 610041, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2019 Mar;50(2):210-214.
OBJECTIVE
To determine the effects of aging on endothelium-dependent vasodilation of human artery.
METHODS
Vessel tension changes induced by acetylcholine (ACh) and endothelial-derived hyperpolarizing factor (EDHF) on gastroepiploic artery rings were recorded in 15 patients with stomach cancer aged between 51 and 83 years. The mRNA expressions of endothelial nitric oxide synthase (), cyclooxygenase (), cystathionineγ lyase () and the C-type natriuretic peptide () in the artery vessels were detected by qRT-PCR.
RESULTS
Both endothelium-dependent and EDHF induced vasodilation decreased with age (<0.05). The mRNA expressions of and also decreased with age (<0.05), except .
CONCLUSION
Aging could impair the function of endothelium-dependent vasodilation and EDHF-induced vasodialtion of human artery, possibly due to decreased NO, H2S and CNP in artery.
目的
确定衰老对人动脉内皮依赖性血管舒张的影响。
方法
记录15例年龄在51至83岁之间的胃癌患者胃网膜动脉环上乙酰胆碱（ACh）和内皮衍生超极化因子（EDHF）诱导的血管张力变化。采用qRT-PCR检测动脉血管中内皮型一氧化氮合酶（）、环氧化酶（）、胱硫醚γ裂解酶（）和C型利钠肽（）的mRNA表达。
结果
内皮依赖性和EDHF诱导的血管舒张均随年龄增长而降低（<0.05）。除了（）外，（）和（）的mRNA表达也随年龄增长而降低（<0.05）。
结论
衰老可能损害人动脉内皮依赖性血管舒张和EDHF诱导的血管舒张功能，可能是由于动脉中NO、H2S和CNP减少所致。
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