National Almazov Medical Research Centre, PET Centre, 2 Akkuratova street, 197341, St. Petersburg, Russia.
N.P. Bechtereva Institute of Human Brain, Russian Academy of Science, Laboratory of Radiochemisty, 9 Ak. Pavlova st., 197376, St. Petersburg, Russia; St.-Petersburg State University, Institute of Chemistry, Universitetskaya Emb., 13B, 199034, St. Petersburg, Russia.
J Pharm Biomed Anal. 2019 Sep 5;173:68-74. doi: 10.1016/j.jpba.2019.05.016. Epub 2019 May 7.
Fluorine-18 labelled radiotracers are the most common diagnostic agents employed in positron emission tomography (PET). Despite well-established quality control (QC) procedures, introduction of new synthetic methods demands continuous development of analytical methodology. Here we propose capillary electrophoresis (CE) as a simple, fast and cost-efficient analytical method, allowing for the evaluation of potentially toxic impurities, including transition metals, in the formulated preparations. Method developed was applied in routine QC procedures for several clinically relevant radiotracers.
氟-18 标记放射性示踪剂是正电子发射断层扫描（PET）中最常用的诊断剂。尽管已经建立了完善的质量控制（QC）程序，但新的合成方法的引入需要不断开发分析方法。在这里，我们提出毛细管电泳（CE）作为一种简单、快速和具有成本效益的分析方法，可用于评估配方制剂中的潜在毒性杂质，包括过渡金属。所开发的方法已应用于几种临床相关放射性示踪剂的常规 QC 程序中。
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