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丹麦全国范围内一项针对 4079 名儿童的研究显示,1 型糖尿病患儿的代谢控制存在社会经济不平等现象。

Socioeconomic Inequality in Metabolic Control Among Children With Type 1 Diabetes: A Nationwide Longitudinal Study of 4,079 Danish Children.

机构信息

Center for Economic Behavior and Inequality, Department of Economics, University of Copenhagen, Copenhagen, Denmark

Department of Economics, Kansas State University, Manhattan, KS.

出版信息

Diabetes Care. 2019 Aug;42(8):1398-1405. doi: 10.2337/dc19-0184. Epub 2019 May 23.

Abstract

OBJECTIVE

To examine inequality in glycemic control by maternal educational level among children with type 1 diabetes in a setting with universal access to health care.

RESEARCH DESIGN AND METHODS

This was a longitudinal nationwide study of 4,079 Danish children with type 1 diabetes between the years 2000 and 2013. Children were divided into four groups based on mothers' education prebirth (≤high school [ = 1,643], vocational or 2-year college [ = 1,548], bachelor's degree [ = 695], ≥master's degree [ = 193]). Means of socioeconomic and treatment characteristics were compared between groups. HbA and the number of daily glucose tests were compared repeatedly from onset until 5 years after onset across groups. HbA was compared across daily blood glucose testing frequency and groups. Linear regression was used to compare HbA across groups with and without adjustment for socioeconomic and treatment characteristics.

RESULTS

Large differences in HbA across maternal education were found. The mean level of HbA during follow-up was 59.7 mmol/mol (7.6%) for children of mothers with ≥master's degrees and 68.7 mmol/mol (8.4%) for children of mothers with ≤high school (difference: 9.0 mmol/mol [95% CI 7.5, 10.6]; 0.8% [95% CI 0.7, 1.0]). The associations were attenuated but remained significant after adjustment. Observable characteristics explained 41.2% of the difference in HbA between children of mothers with ≤high school and mothers with ≥master's degree; 22.5% of the difference was explained by more frequent blood glucose monitoring among the children with the highly educated mothers.

CONCLUSIONS

Family background is significantly related to outcomes for children with type 1 diabetes, even with universal access to health care.

摘要

目的

在医疗保健普及的环境下,研究 1 型糖尿病患儿的母亲教育程度与血糖控制不平等的关系。

研究设计和方法

这是一项针对 2000 年至 2013 年间丹麦 4079 名 1 型糖尿病儿童的全国性纵向研究。根据母亲产前的教育程度(≤高中[=1643]、职业或两年制大学[=1548]、学士学位[=695]、≥硕士学位[=193]),将儿童分为四组。比较组间社会经济和治疗特征的平均值。在不同组间,从发病开始至发病后 5 年,HbA1c 和每日血糖检测次数重复比较。比较 HbA1c 与每日血糖检测频率和组间的关系。线性回归用于比较调整和不调整社会经济和治疗特征后,HbA1c 在组间的差异。

结果

发现 HbA1c 随母亲教育程度的差异较大。在随访期间,母亲为硕士及以上学历儿童的 HbA1c 平均水平为 59.7mmol/mol(7.6%),母亲为高中学历及以下学历儿童的 HbA1c 平均水平为 68.7mmol/mol(8.4%)(差异:9.0mmol/mol[95%CI7.5,10.6];0.8%[95%CI0.7,1.0])。调整后,相关性仍然显著,但有所减弱。可观察到的特征解释了母亲为高中学历和硕士及以上学历的儿童之间 HbA1c 差异的 41.2%;母亲受教育程度较高的儿童中,更频繁的血糖监测解释了 22.5%的差异。

结论

即使在医疗保健普及的情况下,家庭背景与 1 型糖尿病患儿的结局显著相关。

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