[丝裂霉素C（MMC）给药后观察到的微血管病性溶血性贫血（MAHA）]

[Microangiopathic hemolytic anemia (MAHA) observed after administration of mitomycin C (MMC)].

作者信息

Yasunaga C, Komota T, Mimura K, Kinjyo M, Sueishi K, Hirose T

出版信息

Gan No Rinsho. 1987 Jun;33(7):854-60.

Abstract

An autopsy case of MAHA induced by MMC is reported. The patient received MMC and tegafur following operation for colon adenocarcinoma. Five months after the operation, the patient developed MAHA, thrombocytopenia, and renal impairment. MAHA was exacerbated by blood transfusions and he died of extensive pulmonary edema. Autopsy findings showed no residual carcinoma but microangiopathies of the kidney, such as fibrinoid necrosis of the small arteries, arterioles, and glomerular capillaries, and intimal proliferation in the small arteries were evident. As renal impairment is usually irreversible in MAHA by MMC, careful follow-up of renal function should be emphasized in patients receiving MMC.

摘要

报告了一例由丝裂霉素（MMC）诱发的微血管病性溶血性贫血（MAHA）尸检病例。该患者在接受结肠腺癌手术后接受了MMC和替加氟治疗。术后五个月，患者出现MAHA、血小板减少和肾功能损害。输血使MAHA加重，患者死于广泛性肺水肿。尸检结果显示无残留癌，但肾脏存在微血管病变，如小动脉、小动脉和肾小球毛细血管的纤维蛋白样坏死，小动脉内膜增生明显。由于MMC诱发的MAHA中肾功能损害通常不可逆，因此在接受MMC治疗的患者中应强调对肾功能的密切随访。