阿尔茨海默病中合并 TDP-43、路易体病理与神经精神症状的相关性。
Associations between Comorbid TDP-43, Lewy Body Pathology, and Neuropsychiatric Symptoms in Alzheimer's Disease.
机构信息
Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
Department of Environmental and Occupational Health, Epidemiology and Biostatistics Program, University of Nevada Las Vegas, Las Vegas, NV, USA.
出版信息
J Alzheimers Dis. 2019;69(4):953-961. doi: 10.3233/JAD-181285.
More than half of the patients with Alzheimer's disease (AD) have comorbidities including TDP-43 and Lewy bodies, which are also associated with frontotemporal lobar degeneration and dementia with Lewy bodies, respectively. These comorbidities may help explain the overlapping neuropsychiatric symptoms between AD and other dementias. Data on 221 AD patients with Neuropsychiatric Inventory-Questionnaire were obtained from the National Alzheimer's Coordinating Center. TDP-43 was associated with aberrant motor activity, whereas Lewy bodies were associated with anxiety, irritability, sleep behavior, and appetite problems. The associations between these comorbidities and neuropsychiatric symptoms were more significant for patients with sparse diffuse plaques.
超过一半的阿尔茨海默病（AD）患者存在合并症，包括 TDP-43 和路易体，这两种合并症分别与额颞叶变性和路易体痴呆有关。这些合并症可能有助于解释 AD 和其他痴呆症之间重叠的神经精神症状。从国家阿尔茨海默病协调中心获得了 221 名 AD 患者的神经精神疾病问卷数据。TDP-43 与异常运动活动有关，而路易体与焦虑、易怒、睡眠行为和食欲问题有关。对于稀疏弥漫性斑块患者，这些合并症与神经精神症状之间的关联更为显著。
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