Neuhof H, Seeger W, Suttorp N
Prog Clin Biol Res. 1987;236A:289-300.
The pulmonary vasculature and perivascular tissue is able to generate arachidonic acid metabolites with strong effects on vascular tone and permeability. Stimulators of the pulmonary arachidonic acid metabolism, which represents a highly potent mediator system, are components of the classical cascade systems, bacterial toxins, hypoxia, and a variety of other physiological and non-physiological factors. Upon excessive stimulation, the pulmonary circulation responds with vasoconstriction and extravasation. Since granulocytes are always involved, their contribution to the resulting vascular effects has to be considered.
肺血管系统和血管周围组织能够生成对血管张力和通透性有强烈影响的花生四烯酸代谢产物。肺花生四烯酸代谢是一个高效的介质系统，其刺激物包括经典级联系统的成分、细菌毒素、缺氧以及多种其他生理和非生理因素。在受到过度刺激时，肺循环会出现血管收缩和血管外渗反应。由于粒细胞总是参与其中，因此必须考虑它们对所产生的血管效应的作用。
