Fourati Slim, Pawlotsky Jean-Michel
Université Paris Est, Hôpital Henri-Mondor, Centre national de référence des hépatites virales B, C et delta, Service de virologie, 51, avenue du Mal-de-Lattre de Tassigny, 94010 Créteil, France, Inserm U955, 51, avenue du Mal-de-Lattre de Tassigny, 94010 Créteil, France.
Virologie (Montrouge). 2019 Feb 1;23(1):23-34. doi: 10.1684/vir.2019.0760.
Hepatitis B virus (HBV) infects approximately 257 million individuals worldwide. Recent advances in the virology and diagnosis of HBV infection are summarized in this review article. A novel classification of the different phases of chronic HBV infection, proposed by the European Association for the Study of the Liver (EASL), is presented. New diagnostic and monitoring tools are now available, including rapid diagnostic tests for hepatitis B surface antigen (HBsAg) detection, HBsAg quantification assays, an HBV core-related antigen (HBcrAg) quantification test, and HBV RNA quantification testing. Their clinical utility under study is discussed in this review.
全球约有2.57亿人感染乙型肝炎病毒（HBV）。本文综述了HBV感染的病毒学和诊断方面的最新进展。文中介绍了欧洲肝脏研究协会（EASL）提出的慢性HBV感染不同阶段的新分类。目前已有新的诊断和监测工具，包括用于检测乙型肝炎表面抗原（HBsAg）的快速诊断试验、HBsAg定量测定、HBV核心相关抗原（HBcrAg）定量检测以及HBV RNA定量检测。本综述讨论了它们正在研究中的临床应用。
