Kim Kiwon, Yang Hyunju, Na Euihyeon, Lee Hoseon, Jang Ok-Jin, Yoon Hyung-Jun, Oh Hong Seok, Ham Byung-Joo, Park Seon-Cheol, Lin Shih-Ku, Tan Chay Hoon, Shinfuku Naotaka, Park Yong Chon
Department of Psychiatry, Veteran Health Service Medical Center, Seoul, Republic of Korea.
Department of Psychiatry, Jeju National University, Jeju, Republic of Korea.
Psychiatry Investig. 2019 May;16(5):397-402. doi: 10.30773/pi.2019.02.26.4. Epub 2019 May 23.
Based on Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar Disorder, this study tried to present prescription patterns in biopolar disorder (BD) and its associated clinical features. Based on the information obtained from the study with structured questions, the tendency of prescription pattern was studied and analyzed. Polypharmacy was predominant, including simple polypharmacy in 51.1% and complex polypharmacy in 34.2% of patients. Subjects associated with simple or complex polypharmacy were significantly younger, had higher inpatient settings, a larger portion of onset with manic episode, a shorter duration of untreated illness, a shorter duration of current episode, were more overweight, used less antidepressants and used more anxiolytics. These findings can suggest higher polypharmacy rate in more severe BD and highlight the necessity of monitoring the weight of subjects with polypharmacy.
基于韩国双相情感障碍亚洲精神药物处方模式研究的数据，本研究试图呈现双相情感障碍（BD）的处方模式及其相关临床特征。基于通过结构化问题从研究中获得的信息，对处方模式的趋势进行了研究和分析。联合用药占主导，其中51.1%的患者为单纯联合用药，34.2%的患者为复杂联合用药。与单纯或复杂联合用药相关的受试者明显更年轻，住院率更高，躁狂发作起病的比例更大，未治疗疾病的持续时间更短，当前发作的持续时间更短，超重情况更多，使用抗抑郁药较少且使用抗焦虑药较多。这些发现表明，在更严重的双相情感障碍中联合用药率更高，并突出了监测联合用药受试者体重的必要性。
