From the Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Florida Health; and the Department of Plastic Surgery, University of California, Irvine.
Plast Reconstr Surg. 2019 Jun;143(6):1625-1632. doi: 10.1097/PRS.0000000000005617.
Given the widespread utility and therapeutic potential of autogenous fat grafting, plastic surgeons should be familiar with its safety profile and associated adverse events. This article provides a critical review of the literature and delineates risk factors associated with various complications when grafting to the breast and gluteal regions. The majority of adverse events are related to fat necrosis and require minimal diagnostic or therapeutic intervention. Larger graft volumes, as in cosmetic augmentation, are associated with higher incidences of fatty necrosis. The oncologic safety of fat grafting is supported by multiple clinical studies with thousands of breast cancer patients, albeit predominantly retrospective in nature. Although less frequent, serious complications include fat emboli during gluteal augmentation. Identification of associated risk factors and implementation of proper surgical techniques may minimize the occurrence of life-threatening complications.
鉴于自体脂肪移植的广泛应用和治疗潜力，整形医生应该熟悉其安全性概况和相关不良事件。本文对文献进行了批判性回顾，并阐述了在乳房和臀部区域进行移植时与各种并发症相关的危险因素。大多数不良事件与脂肪坏死有关，只需进行最小的诊断或治疗干预。在美容隆乳中，较大的移植物体积与更高的脂肪坏死发生率相关。多项数千例乳腺癌患者的临床研究支持脂肪移植的肿瘤安全性，尽管这些研究主要是回顾性的。虽然不太常见，但严重的并发症包括臀部增大时的脂肪栓塞。识别相关危险因素并实施适当的手术技术可能会最大限度地减少危及生命的并发症的发生。
