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肝移植术后早期李斯特菌病:两例报告。

Early listeriosis after liver transplantation: Report of two cases.

作者信息

Piette Estelle, Vandermeulen Morgan, Meurisse Nicolas, Schielke Astrid, Meuris Christelle, Honoré Pierre, Detry Olivier

机构信息

Department of Abdominal and Transplant Surgery, CHU Liege, University of Liege (CHU ULiege), Liege, Belgium.

Department of Internal Medicine and Infectious Diseases, CHU Liege, University of Liege (CHU ULiege), Liege, Belgium.

出版信息

Transpl Infect Dis. 2019 Aug;21(4):e13122. doi: 10.1111/tid.13122. Epub 2019 Jun 30.

Abstract

Listeria monocytogenes is a rare cause of potentially lethal infection and sepsis in transplant recipients. Listeriosis is usually described after kidney or bone marrow transplant, and has been less frequently reported after liver transplantation. Here, the authors present two cases of severe Listeria infection occurring within 4 months after complicated liver transplantation in patients still recovering on the ward. The patients were successfully treated by intravenous ampicillin. These cases should remind transplant physicians that listeriosis may develop in liver transplant recipients, that food safety advice should be provided, and that intravenous ampicillin might be an effective treatment for systemic listeriosis in solid organ recipients. It is likely that trimethoprim-sulfamethoxazole prophylaxis might help prevent early listeriosis after solid organ transplantation.

摘要

单核细胞增生李斯特菌是移植受者发生潜在致命感染和败血症的罕见病因。李斯特菌病通常在肾移植或骨髓移植后出现,而在肝移植后报告较少。在此,作者介绍了两例复杂肝移植术后4个月内发生严重李斯特菌感染的病例,患者仍在病房恢复中。患者通过静脉注射氨苄西林成功治愈。这些病例应提醒移植医生,肝移植受者可能发生李斯特菌病,应提供食品安全建议,静脉注射氨苄西林可能是实体器官受者全身性李斯特菌病的有效治疗方法。甲氧苄啶-磺胺甲恶唑预防用药可能有助于预防实体器官移植后的早期李斯特菌病。

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