基因多态性与中国汉族人群膀胱癌的相关性研究。
Association between Gene Polymorphisms and Bladder Cancer in Chinese Han Population.
机构信息
Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
出版信息
Dis Markers. 2019 Apr 15;2019:3949343. doi: 10.1155/2019/3949343. eCollection 2019.
BACKGROUND
Previous evidence has indicated that the reduction of axis inhibition protein 1 () expression is related with the poor differentiation of non-small-cell lung cancer (NSCLC). However, the potential association between AXIN1 and bladder cancer (BC) is unknown. We aimed to initially explore the relevance of gene polymorphisms (rs12921862 C/A, rs1805105 T/C, and rs370681 C/T) and BC.
METHODS
Three hundred and sixteen BC patients and 419 healthy controls had been enrolled. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for genotyping three tag single-nucleotide polymorphisms (SNPs) of . The SNPstats online analysis software and SPSS software were used for statistical analysis.
RESULTS
Our data revealed that three tag SNPs were associated with an increased risk of BC (rs12921862: < 0.001, OR (95%CI) = 4.61 (3.13-6.81); rs1805105: = 0.046, OR (95%CI) = 1.35 (1.00-1.82); and rs370681: = 0.004, OR (95%CI) = 1.56 (1.15-2.10)). For rs12921862, A allele was an independently protective factor which correlated with a better prognosis in non-muscle-invasive bladder cancer (NMIBC) patients ( = 0.03, OR (95%CI) = 0.10 (0.01-0.84)). Stratification analysis demonstrated that rs370681 polymorphism was related with high-grade bladder cancer ( = 0.04, OR (95%CI) = 1.85 (1.04-3.23)).
CONCLUSION
The gene polymorphisms might implicate in BC risk, and rs12921862 could be a potential forecasting factor for prognosis of BC patients.
背景
先前的证据表明，轴抑制蛋白 1 () 表达的减少与非小细胞肺癌 (NSCLC) 的分化不良有关。然而，AXIN1 与膀胱癌 (BC) 之间的潜在关联尚不清楚。我们旨在初步探讨基因多态性 (rs12921862C/A、rs1805105T/C 和 rs370681C/T) 与 BC 的相关性。
方法
纳入 316 例 BC 患者和 419 例健康对照者。采用聚合酶链反应-限制性片段长度多态性 (PCR-RFLP) 方法对 3 个标签单核苷酸多态性 (SNP)rs12921862C/A、rs1805105T/C 和 rs370681C/T 进行基因分型。使用 SNPstats 在线分析软件和 SPSS 软件进行统计分析。
结果
我们的数据显示，三个标签 SNP 与 BC 风险增加相关(rs12921862：<0.001，OR(95%CI)=4.61(3.13-6.81)；rs1805105：=0.046，OR(95%CI)=1.35(1.00-1.82)；rs370681：=0.004，OR(95%CI)=1.56(1.15-2.10))。对于 rs12921862，A 等位基因是一个独立的保护因素，与非肌肉浸润性膀胱癌 (NMIBC) 患者的较好预后相关(=0.03，OR(95%CI)=0.10(0.01-0.84))。分层分析表明，rs370681 多态性与高级别膀胱癌相关(=0.04，OR(95%CI)=1.85(1.04-3.23))。
结论
基因多态性可能与 BC 风险相关，rs12921862 可能是 BC 患者预后的潜在预测因子。
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