a Department of Neurosurgery , Brain Center Rudolph Magnus, University Medical Centre Utrecht , Utrecht , The Netherlands.
b Brain Technology Institute , Utrecht , The Netherlands.
Expert Rev Med Devices. 2019 Jul;16(7):549-553. doi: 10.1080/17434440.2019.1626232. Epub 2019 Jun 3.
: Cerebrospinal fluid leakage is a complication after intradural surgery and is associated with severe secondary complications like compromised wound healing and meningitis. Dural sealants are meant to augment the primary dural closure in order to achieve a watertight closure. : This review summarizes the efficacy of currently available dural sealants. Potential future improvements and biomaterials are discussed. : The use of a dural sealant seems to be the logical method to prevent CSF leakage. However, based on the efficacy of currently available dural sealants according to systematic reviews and studies, a significant effective dural sealant seems is still lacking. A new dural sealant has to be thoroughly assessed before clinical application in , in vivo and clinical trials. A new research area within sealant development might be the introduction of dural sealants with both antimicrobial and analgesic properties.
脑脊液漏是硬脊膜内手术后的一种并发症，可导致严重的继发性并发症，如伤口愈合不良和脑膜炎。硬脑膜密封剂旨在增强主要硬脑膜闭合，以实现密封。
本综述总结了目前可用的硬脑膜密封剂的疗效。讨论了潜在的未来改进和生物材料。
使用硬脑膜密封剂似乎是预防 CSF 渗漏的合理方法。然而，根据系统评价和研究中目前可用的硬脑膜密封剂的疗效，似乎仍然缺乏一种有效的硬脑膜密封剂。在临床应用之前，一种新的硬脑膜密封剂必须在体内和临床试验中进行彻底评估。在密封剂开发的新研究领域可能是引入具有抗菌和镇痛特性的硬脑膜密封剂。
