Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, China; Institute of Cell Therapy, The Third Affiliated Hospital of Soochow University, Changzhou, China; Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, China; Institute of Cell Therapy, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Acta Histochem. 2019 Jul;121(5):657-663. doi: 10.1016/j.acthis.2019.05.009. Epub 2019 May 30.
The prognostic significance and clinical implications of resident CD103CD8T cells in human colorectal cancer tissues still remains largely unexplored. In our present study, we aimed to characterize the resident CD8T cells in human colorectal cancer tissues by using double staining of CD103 and CD8, and further evaluated the prognostic significance of resident CD8T cells in colorectal cancer. We found that the OS rate of the colorectal cancer patients with higher infiltration of CD8T cells, or with higher numbers of resident CD103CD8T cells, or with higher ratio of CD103CD8T cells over total CD8T cells in cancer tissues was significantly better than that of the patients with lower infiltration of CD8T cells, or with lower numbers of resident CD103CD8T cells, or with higher ratio of CD103CD8T cells over total CD8T cells in cancer tissues, respectively. Moreover, higher infiltration of CD8T cells in colorectal cancer tissues was significantly and inversely correlated with advanced TNM stage. Higher numbers of resident CD103CD8T cells in colorectal cancer tissues were significantly and inversely correlated with distant metastasis status. Higher ratio of CD103CD8T cells over total CD8T cells in colorectal cancer tissues was significantly and inversely correlated with age status. The COX model analysis demonstrated that higher infiltration of CD8T cells, higher numbers of resident CD103CD8T cells, or higher ratio of CD103CD8T cells over total CD8T cells in colorectal cancer tissues, could serve as independent prognostic predictors for colorectal cancer patients. Taken together, our present study demonstrated the density of tumor infiltrating CD8T cells or the numbers of resident CD103CD8T cells in colorectal tissues could be used as an important prognostic predictor for this malignancy.
在人类结直肠癌组织中，驻留 CD103+CD8+T 细胞的预后意义和临床意义在很大程度上仍未得到探索。在本研究中，我们旨在通过 CD103 和 CD8 的双重染色来描述人类结直肠癌组织中的驻留 CD8+T 细胞，并进一步评估驻留 CD8+T 细胞在结直肠癌中的预后意义。我们发现，结直肠癌患者的 OS 率与肿瘤组织中 CD8+T 细胞浸润程度较高、驻留 CD103+CD8+T 细胞数量较多、或 CD103+CD8+T 细胞与总 CD8+T 细胞比值较高呈正相关，与 CD8+T 细胞浸润程度较低、驻留 CD103+CD8+T 细胞数量较少、或 CD103+CD8+T 细胞与总 CD8+T 细胞比值较高呈负相关。此外，结直肠癌组织中 CD8+T 细胞浸润程度与 TNM 分期较晚显著相关，驻留 CD103+CD8+T 细胞数量与远处转移状态显著相关，CD103+CD8+T 细胞与总 CD8+T 细胞比值与年龄状态显著相关。COX 模型分析表明，结直肠癌组织中 CD8+T 细胞浸润程度较高、驻留 CD103+CD8+T 细胞数量较多、或 CD103+CD8+T 细胞与总 CD8+T 细胞比值较高，均可作为结直肠癌患者的独立预后预测因子。综上所述，本研究表明结直肠组织中肿瘤浸润 CD8+T 细胞的密度或驻留 CD103+CD8+T 细胞的数量可作为该恶性肿瘤的重要预后预测因子。
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