Division of Rheumatology, Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, South Korea.
Division of Cardiology, Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Aran 13gil (Ara-1-dong), Jeju-Si, Jeju, 63241, South Korea.
Rheumatol Int. 2019 Jul;39(7):1249-1255. doi: 10.1007/s00296-019-04313-9. Epub 2019 Jun 1.
The objective of this study is to determine whether the presence of tophi could predict an increase in arterial stiffness. Between June 2017 and June 2018, the augmentation index (AI) was measured using SphygmoCor for patients with gout who visited the Jeju National University Hospital in South Korea. Patients were divided into the following groups: group with tophi and group without tophi. Medical records, laboratory data, and AI were retrospectively analyzed. One hundred and twenty patients with gout or participated in the study, with most (96.7%) of the patients being male. The mean duration of the disease was 7.0 years. At the time of the examination, 99 patients (82.5%) were treated with a uric acid-lowering agent. Of the total patients, 24 (19.7%) had tophi. Patients with tophi were significantly older (60.2 ± 11.6 years vs. 53.8 ± 13.0 years, p = 0.031), had longer disease duration (13.0 ± 6.5 years vs 5.5 ± 5.4 years, p < 0.001), and higher AI@75 (28.7 ± 7.8 vs 20.9 ± 10.0, p = 0.001) than those without tophi. In the multiple linear regression analysis, tophi was shown to be a significant predictor of high AI (p = 0.040). The presence of tophi is a predictor of increased arterial stiffness in patients with gout. Therefore, more strict control of cardiovascular disease risk factors is needed in the treatment of patients with tophi.
本研究旨在确定痛风石的存在是否可以预测动脉僵硬度的增加。2017 年 6 月至 2018 年 6 月期间，对韩国济州国立大学医院就诊的痛风患者使用 SphygmoCor 测量了增强指数（AI）。患者分为有痛风石组和无痛风石组。回顾性分析了病历、实验室数据和 AI。共有 120 名痛风患者参与了本研究，其中大多数（96.7%）为男性。疾病的平均病程为 7.0 年。在检查时，99 名患者（82.5%）正在服用降尿酸药物。在所有患者中，24 名（19.7%）有痛风石。有痛风石的患者明显年龄更大（60.2±11.6 岁 vs. 53.8±13.0 岁，p=0.031），病程更长（13.0±6.5 年 vs. 5.5±5.4 年，p<0.001），AI@75 更高（28.7±7.8 vs. 20.9±10.0，p=0.001）。多元线性回归分析显示，痛风石是 AI 升高的显著预测因素（p=0.040）。痛风石的存在是痛风患者动脉僵硬度增加的预测因素。因此，在治疗有痛风石的患者时，需要更严格地控制心血管疾病的危险因素。
