基因调控：转录因子梯度的模拟到数字转换。

Gene Regulation: Analog to Digital Conversion of Transcription Factor Gradients.

机构信息

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

Max-Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

出版信息

Curr Biol. 2019 Jun 3;29(11):R422-R424. doi: 10.1016/j.cub.2019.04.052.

DOI:10.1016/j.cub.2019.04.052

PMID:31163148

Abstract

Transcription factor gradients trigger differential transcriptional responses based on concentration. But how, in some cases, do target genes maintain uniform transcription across portions of the gradient? Lessons from Drosophila demonstrate that organization of transcription into 'hubs' can lead to local increases in transcription factor concentration.

摘要

转录因子梯度根据浓度引发不同的转录反应。但是，在某些情况下，靶基因如何在梯度的一部分保持均匀的转录？来自果蝇的研究表明，转录组织成“枢纽”可以导致转录因子浓度的局部增加。