前列腺癌诊断时基础总睾酮循环水平与肿瘤分级组之间的正相关关系。

Positive Association between Basal Total Testosterone Circulating Levels and Tumor Grade Groups at the Time of Diagnosis of Prostate Cancer.

作者信息

Porcaro Antonio B, Tafuri Alessandro, Sebben Marco, Pirozzi Marco, Processali Tania, Rizzetto Riccardo, Amigoni Nelia, Shakir Aliasger, Tiso Leone, Cerrato Clara, Panunzio Andrea, De Michele Mario, Cerruto Maria Angela, Brunelli Matteo, Migliorini Filippo, Siracusano Salvatore, Artibani Walter

机构信息

Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy,

Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.

出版信息

Urol Int. 2019;103(4):400-407. doi: 10.1159/000500960. Epub 2019 Jun 4.

DOI:10.1159/000500960

PMID:31163438

Abstract

INTRODUCTION

To test the hypothesis that basal total testosterone (TT) levels are associated with International Society of Urologic Pathology (ISUP) tumor grade groups at the time of diagnosis of prostate cancer (PCA).

METHODS

From November 2014 to March 2018, preoperative TT and PSA were measured in 601 consecutive patients who were not under androgen deprivation and undergoing surgery for PCA. Patients were classified into low (ISUP 1; reference group), intermediate (ISUP 2/3), and high (ISUP 4/5) tumor grade groups. The association of TT and other clinical factors with tumor groups was evaluated by multinomial multivariate regression analysis.

RESULTS

218 patients (36.3%) were biopsy low grade (ISUP 1), 297 (49.4%) intermediate grade (ISUP 2/3), and 86 (14.3) high grade (ISUP 4/5). Median basal circulating TT levels progressively increased as tumor grade groups increased. On multivariate models, TT, among other clinical factors, was positively associated with the risk of intermediate (OR 1.001; p = 0.023) and high tumor grades (OR 1.002, p = 0.022) compared to low-grade cancers.

CONCLUSIONS

Increased endogenous circulating basal TT levels were positively associated with ISUP tumor grade groups at the time of diagnosis indicating a close association with tumor biology. Basal TT levels may reflect the heterogeneity of the cancer population.

摘要

引言

为验证前列腺癌（PCA）诊断时基础总睾酮（TT）水平与国际泌尿病理学会（ISUP）肿瘤分级组相关的假设。

方法

2014年11月至2018年3月，对601例未接受雄激素剥夺治疗且因PCA接受手术的连续患者测量术前TT和PSA。患者被分为低（ISUP 1；参照组）、中（ISUP 2/3）和高（ISUP 4/5）肿瘤分级组。通过多项多变量回归分析评估TT及其他临床因素与肿瘤组的相关性。

结果

218例患者（36.3%）活检为低级别（ISUP 1），297例（49.4%）为中级（ISUP 2/3），86例（14.3%）为高级别（ISUP 4/5）。基础循环TT水平中位数随肿瘤分级组增加而逐渐升高。在多变量模型中，与低级别癌症相比，TT及其他临床因素与中级（OR 1.001；p = 0.023）和高级别肿瘤风险（OR 1.002，p = 0.022）呈正相关。