通过亚胺基自由基光氧化还原催化的O-酰基肟与二氧化硫插入反应的磺酰化反应
Photoredox-Catalyzed Sulfonylation of O-Acyl Oximes via Iminyl Radicals with the Insertion of Sulfur Dioxide.
作者信息
Zhang Jun, Li Xiaofang, Xie Wenlin, Ye Shengqing, Wu Jie
机构信息
Department of Chemistry , Fudan University , 2005 Songhu Road , Shanghai 200438 , China.
School of Pharmaceutical and Materials Engineering & Institute for Advanced Studies , Taizhou University , 1139 Shifu Avenue , Taizhou 318000 , China.
出版信息
Org Lett. 2019 Jul 5;21(13):4950-4954. doi: 10.1021/acs.orglett.9b01323. Epub 2019 Jun 10.
A multicomponent sulfonylation of O-acyl oximes via iminyl radicals with the insertion of sulfur dioxide under photoredox catalysis is achieved. This multicomponent reaction of O-acyl oximes, potassium metabisulfite, alkenes, and nucleophiles under visible-light irradiation is efficient, giving rise to a range of sulfones in moderate to good yields. A broad reaction scope is presented with good functional group compatibility.
实现了在光氧化还原催化下通过亚胺基自由基对O-酰基肟进行多组分磺酰化反应，并插入二氧化硫。在可见光照射下，O-酰基肟、焦亚硫酸钾、烯烃和亲核试剂的这种多组分反应是高效的，能以中等至良好的产率得到一系列砜。该反应具有广泛的反应范围和良好的官能团兼容性。
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