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DNA 损伤因子 RNF8 在癌症发病机制和进展中的作用。

The Functions of DNA Damage Factor RNF8 in the Pathogenesis and Progression of Cancer.

机构信息

Institute of Translational Medicine, China Medical University; Key Laboratory of Medical Cell Biology, Ministry of Education; Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, Shenyang, Liaoning Province, China.

Department of Anus and Intestine Surgery, First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.

出版信息

Int J Biol Sci. 2019 Mar 9;15(5):909-918. doi: 10.7150/ijbs.31972. eCollection 2019.

DOI:10.7150/ijbs.31972
PMID:31182912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6535783/
Abstract

The really interesting new gene (RING) finger protein 8 (RNF8) is a central factor in DNA double strand break (DSB) signal transduction. DSB damage is the most toxic type of DNA damage to cells and is related to genomic instability. Multiple roles for RNF8 have been identified in DNA damage response as well as in other functions, such as telomere protection, cell cycle control and transcriptional regulation. These functions are closely correlated to tumorigenesis and cancer progression. Indeed, deficiency of RNF8 caused spontaneous tumorigenesis in a mouse model. Deciphering these mechanisms of RNF8 may shed light on strategies for cancer treatment. In this review, we summarize the current understanding of both classical and nonclassical functions of RNF8, and discuss its roles in the pathogenesis and progression of tumor.

摘要

真核生物中富含亮氨酸重复序列蛋白 8（RING）是 DNA 双链断裂（DSB）信号转导的核心因子。DSB 损伤是细胞中最具毒性的 DNA 损伤类型，与基因组不稳定性有关。在 DNA 损伤反应以及其他功能（如端粒保护、细胞周期控制和转录调控）中，已经确定了 RNF8 的多种作用。这些功能与肿瘤发生和癌症进展密切相关。事实上，在小鼠模型中，RNF8 的缺失会导致自发性肿瘤发生。阐明 RNF8 的这些机制可能为癌症治疗策略提供启示。在这篇综述中，我们总结了 RNF8 的经典和非经典功能的最新认识，并讨论了它在肿瘤发病机制和进展中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5122/6535783/ab831c940ecf/ijbsv15p0909g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5122/6535783/e3913ecde0a6/ijbsv15p0909g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5122/6535783/ab831c940ecf/ijbsv15p0909g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5122/6535783/e3913ecde0a6/ijbsv15p0909g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5122/6535783/ab831c940ecf/ijbsv15p0909g002.jpg

相似文献

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The Functions of DNA Damage Factor RNF8 in the Pathogenesis and Progression of Cancer.

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[7]
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[8]
Markers for DNA damage are induced in the rat colon by the toxin altertoxin-II, but not a complex extract of cultured .

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[9]
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本文引用的文献

[1]
Spatiotemporal regulation of the Dma1-mediated mitotic checkpoint coordinates mitosis with cytokinesis.

Curr Genet. 2019-1-2

[2]
LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERα pathway.

Nat Commun. 2018-10-9

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Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.

J Clin Invest. 2018-8-2

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CA Cancer J Clin. 2018-9-12

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L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage.

Nat Cell Biol. 2018-3-26

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Cancer Treat Rev. 2017-11-13

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miR-125a-3p inhibits ERα transactivation and overrides tamoxifen resistance by targeting CDK3 in estrogen receptor-positive breast cancer.

FASEB J. 2018-1-4

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RNF8 identified as a co-activator of estrogen receptor α promotes cell growth in breast cancer.

Biochim Biophys Acta Mol Basis Dis. 2017-2-12

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FEBS Lett. 2017-3

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