Kelly M E, Lawlor B A, Coen R F, Robertson I H, Brennan S
1Department of Psychology,John Hume Building,Maynooth University,Co. Kildare,Ireland.
2Institute of Neuroscience, Trinity College Dublin,Dublin,Ireland.
Ir J Psychol Med. 2019 Jun;36(2):105-119. doi: 10.1017/ipm.2017.23.
Research shows that cognitive rehabilitation (CR) has the potential to improve goal performance and enhance well-being for people with early stage Alzheimer's disease (AD). This single subject, multiple baseline design (MBD) research investigated the clinical efficacy of an 8-week individualised CR intervention for individuals with early stage AD.
Three participants with early stage AD were recruited to take part in the study. The intervention consisted of eight sessions of 60-90 minutes of CR. Outcomes included goal performance and satisfaction, quality of life, cognitive and everyday functioning, mood, and memory self-efficacy for participants with AD; and carer burden, general mental health, quality of life, and mood of carers.
Visual analysis of MBD data demonstrated a functional relationship between CR and improvements in participants' goal performance. Subjective ratings of goal performance and satisfaction increased from baseline to post-test for three participants and were maintained at follow-up for two. Baseline to post-test quality of life scores improved for three participants, whereas cognitive function and memory self-efficacy scores improved for two.
Our findings demonstrate that CR can improve goal performance, and is a socially acceptable intervention that can be implemented by practitioners with assistance from carers between sessions. This study represents one of the promising first step towards filling a practice gap in this area. Further research and randomised-controlled trials are required.
研究表明,认知康复(CR)有潜力改善早期阿尔茨海默病(AD)患者的目标表现并提升幸福感。这项单受试者、多基线设计(MBD)研究调查了为期8周的个体化CR干预对早期AD患者的临床疗效。
招募了三名早期AD患者参与研究。干预包括八节时长60 - 90分钟的CR课程。结果包括AD患者的目标表现与满意度、生活质量、认知和日常功能、情绪以及记忆自我效能;以及照顾者的负担、总体心理健康、生活质量和情绪。
对MBD数据的视觉分析表明CR与参与者目标表现的改善之间存在功能关系。三名参与者的目标表现和满意度主观评分从基线到测试后有所提高,其中两名参与者在随访时保持该水平。三名参与者的生活质量评分从基线到测试后有所改善;两名参与者的认知功能和记忆自我效能评分有所改善。
我们的研究结果表明,CR可以改善目标表现,是一种社会可接受的干预措施,从业者在照顾者的协助下可在课程间隙实施。这项研究是填补该领域实践空白的有前景的第一步之一。还需要进一步的研究和随机对照试验。