Healy Sarah, Simpson Mark, Kitchen William J, Jacob Anu, Crooks Daniel, Rathi Nitika, Biswas Shubhabrata, Fletcher Nicholas, Huda Saif, Sekhar Alakendu
Department of Neurology, Walton Centre Foundation Trust, Liverpool, UK.
Department of Neurology, Walton Centre Foundation Trust, Lower Lane, Fazarkerley, Liverpool L9 7LJ, UK,
J R Coll Physicians Edinb. 2019 Jun;49(2):118-121. doi: 10.4997/JRCPE.2019.206.
Giant cell arteritis is the most common primary systemic vasculitis in adults aged ≥50 years and peaks in the eighth decade of life. Common symptoms include headache, scalp tenderness and jaw claudication. Elevated acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) are present in >90% of patients. Visual loss is a well-recognised complication, but approximately 2-4% of giant cell arteritis patients experience stroke, most frequently in the vertebrobasilar territory. We describe a 72-year-old male who developed bilateral vertebral artery occlusion and middle cerebellar peduncle infarction secondary to giant cell arteritis in spite of high-dose steroids.
巨细胞动脉炎是≥50岁成年人中最常见的原发性系统性血管炎,在80岁时达到发病高峰。常见症状包括头痛、头皮压痛和颌部间歇性运动障碍。超过90%的患者急性期反应物(红细胞沉降率和C反应蛋白)升高。视力丧失是一种公认的并发症,但约2-4%的巨细胞动脉炎患者会发生中风,最常见于椎基底动脉区域。我们描述了一名72岁男性,尽管使用了大剂量类固醇,但仍继发于巨细胞动脉炎而发生双侧椎动脉闭塞和小脑中脚梗死。