Giglio Benjamin C, Wang Hui, Yan Xuefeng, Li Zibo
Department of Radiology and Biomedical Research Imaging Center , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , USA . Email:
Medchemcomm. 2019 Apr 15;10(5):814-816. doi: 10.1039/c9md00082h. eCollection 2019 May 1.
A synthetic approach is established to achieve radioactive 5-I-α-methyl-tryptophan (5-I-AMT). An enzyme based assay demonstrated that 5-I-AMT is a substrate of IDO-1. The distribution and imaging potential of 5-I-AMT were explored with a B16F10 tumor model using I-124 as the radiotag.
已建立一种合成方法来制备放射性5-I-α-甲基色氨酸(5-I-AMT)。基于酶的分析表明5-I-AMT是吲哚胺2,3-双加氧酶-1(IDO-1)的底物。使用I-124作为放射性标记物,通过B16F10肿瘤模型探索了5-I-AMT的分布和成像潜力。