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虚弱和肌少症对复杂脊柱手术后患者结局的影响。

The impact of frailty and sarcopenia on patient outcomes after complex spine surgery.

机构信息

Department of Anesthesiology and Perioperative Care, Vancouver General Hospital.

Department of Anesthesiology, Pharmacology and Therapeutics.

出版信息

Curr Opin Anaesthesiol. 2019 Oct;32(5):609-615. doi: 10.1097/ACO.0000000000000759.

Abstract

PURPOSE OF REVIEW

Frailty and sarcopenia represent a state of increased fragility and decreased reserve, and both have been associated with worse outcomes after surgery. The present review focuses on the definitions and measurement tools used to assess frailty and sarcopenia in patients with spinal disorder, and the relationships between frailty, sarcopenia, and postoperative outcomes in patients undergoing complex spine surgery.

RECENT FINDINGS

Complex spine surgery is associated with a high rate of adverse events when using a validated, prospective data collection system. Recent studies have demonstrated that patients with spine surgery with frailty and sarcopenia have a higher risk of adverse events, although this relationship varies depending on the measurement tool and specific population studied. Both general and specific frailty assessment tools have been used in the spine surgery population, however the optimal tool is not known. Spinal disorders such as lumbar stenosis contribute to the frailty phenotype, and may be reversible with surgery.

SUMMARY

Frailty and sarcopenia are increasingly recognized as important predictors of adverse outcomes after complex spine surgery. The optimal tool to measure frailty and sarcopenia in patients with spinal disorders remains unclear, and the role of surgery as an intervention to reverse frailty requires further investigation.

摘要

目的综述

虚弱和肌少症代表一种脆弱性增加和储备减少的状态,两者均与手术后的不良结局相关。本综述重点关注用于评估脊柱疾病患者虚弱和肌少症的定义和测量工具,以及在接受复杂脊柱手术的患者中,虚弱、肌少症与术后结局之间的关系。

最新发现

使用经过验证的前瞻性数据收集系统,复杂脊柱手术与不良事件的发生率较高相关。最近的研究表明,患有虚弱和肌少症的脊柱手术患者发生不良事件的风险更高,尽管这种关系因所使用的测量工具和具体研究人群而异。一般和特定的虚弱评估工具已在脊柱手术人群中使用,但最佳工具尚不清楚。腰椎狭窄等脊柱疾病导致虚弱表型,且可能通过手术逆转。

总结

虚弱和肌少症日益被认为是复杂脊柱手术后不良结局的重要预测因素。用于评估脊柱疾病患者虚弱和肌少症的最佳工具仍不清楚,手术作为逆转虚弱的干预措施的作用需要进一步研究。

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