支持Rap2a GTP酶在脂多糖介导的先天免疫反应和核因子κB激活中的表达、激活及作用的数据。

Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-κB activation.

作者信息

Carvalho Brener C, Oliveira Leonardo C, Rocha Carolina D, Fernandes Heliana B, Oliveira Isadora M, Leãõ Felipe B, Valverde Thalita M, Rego Igor M G, Ghosh Sankar, Silva Aristóbolo M

机构信息

Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

Department of Microbiology & Immunology, College of Physicians & Surgeons, Columbia University, New York, NY, USA.

出版信息

Data Brief. 2019 May 2;24:103965. doi: 10.1016/j.dib.2019.103965. eCollection 2019 Jun.

DOI:10.1016/j.dib.2019.103965

PMID:31193517

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6531833/

Abstract

We present here the data to support the understanding of the implication of Rap2a GTPase in LPS-induced innate immune response and NF-κB activation. The data presented are related to molecular tools that were generated, acquired, optimized or validated to investigate Rap2a expression, activation and its effects in mammalian cells including RAW264.7 macrophages and THP-1 monocytes under inflammatory conditions. These data supplement important technical and biological information on immune function of Rap2a in macrophages activated by LPS, recently reported by us (Carvalho et al., 2019) [1].

摘要

我们在此展示数据，以支持对Rap2a GTP酶在脂多糖诱导的先天性免疫反应和核因子κB激活中的作用的理解。所呈现的数据与为研究Rap2a在炎症条件下的表达、激活及其在包括RAW264.7巨噬细胞和THP-1单核细胞在内的哺乳动物细胞中的作用而生成、获取、优化或验证的分子工具相关。这些数据补充了我们最近报道的（Carvalho等人，2019年）[1]关于脂多糖激活的巨噬细胞中Rap2a免疫功能的重要技术和生物学信息。