Xiang Yuchen, Bunpetch Varitsara, Zhou Wenyan, Ouyang Hongwei
Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
2nd Affiliated Hospital & ZJU-UOE Institute Zhejiang University School of Medicine, Hangzhou, China.
J Orthop Translat. 2019 Jan 29;17:3-14. doi: 10.1016/j.jot.2018.12.005. eCollection 2019 Apr.
Bearing compression from adjacent joints, the articular cartilage is cumulatively pressured in daily life, thus making it prone to injuries; however, once damaged, the self-healing capacity of articular cartilage is limited owing to its low metabolic property. Autologous chondrocyte implantation, a three-step repairing technique for articular lesions, has received satisfactory short-term clinical outcomes, whereas its long-term effect remains controversial. Currently, improved stem-cell therapies and novel biomaterials have shed new lights on autologous chondrocyte implantation. We would, therefore, synthesize these optimization strategies in order of their presences in the three-step protocol, seeking to find and amplify synergic effects between these strategies.
Autologous chondrocytes implantation serves as an alternative for the treatment of articular cartilage lesions to avoid potentially detrimental effects of applying microfracture. The optimized ACI should improve the cost-effectiveness of repairing articular cartilage while circumventing latent complications like osteophyte. This article synthesized optimization strategies for ACI and provided appropriate applying approaches to maximize their synergic effects. It will be a pioneering trial for combinedly using stem cells and nanotechnology to regenerate cartilage.
由于相邻关节的承重压力，关节软骨在日常生活中会受到累积压力，因此容易受伤；然而，一旦受损，由于其低代谢特性，关节软骨的自我修复能力有限。自体软骨细胞植入是一种用于关节损伤的三步修复技术，已取得了令人满意的短期临床效果，但其长期效果仍存在争议。目前，改进的干细胞疗法和新型生物材料为自体软骨细胞植入带来了新的曙光。因此，我们将按照这些优化策略在三步方案中的出现顺序对其进行综合，试图找到并放大这些策略之间的协同效应。
自体软骨细胞植入可作为治疗关节软骨损伤的一种替代方法，以避免应用微骨折可能产生的有害影响。优化后的自体软骨细胞植入应提高修复关节软骨的成本效益，同时规避诸如骨赘等潜在并发症。本文综合了自体软骨细胞植入的优化策略，并提供了适当的应用方法以最大化其协同效应。这将是联合使用干细胞和纳米技术再生软骨的开创性试验。
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