Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
South London and Maudsley NHS Foundation Trust, King's College London, London, UK.
BMJ Open. 2019 Jun 12;9(6):e028929. doi: 10.1136/bmjopen-2019-028929.
To investigate recorded poor insight in relation to mental health and service use outcomes in a cohort with first-episode psychosis.
We developed a natural language processing algorithm to ascertain statements of poor or diminished insight and tested this in a cohort of patients with first-episode psychosis.
The clinical record text at the South London and Maudsley National Health Service Trust in the UK was used.
We applied the algorithm to characterise a cohort of 2026 patients with first-episode psychosis attending an early intervention service.
Recorded poor insight within 1 month of registration was investigated in relation to (1) incidence of psychiatric hospitalisation, (2) odds of legally enforced hospitalisation, (3) number of days spent as a mental health inpatient and (4) number of different antipsychotic agents prescribed; outcomes were measured over varying follow-up periods from 12 months to 60 months, adjusting for a range of sociodemographic and clinical covariates.
Recorded poor insight, present in 48.9% of the sample, was positively associated with youngest and oldest age groups, unemployment and schizophrenia (compared with bipolar disorder) and was negatively associated with Asian ethnicity, married status, home ownership and recorded cannabis use. It was significantly associated with higher levels of all four outcomes over the succeeding 12 months. Associations with hospitalisation incidence and number of antipsychotics remained independently significant when measured over 60 and 48 months, respectively.
Recorded poor insight in people with recent onset psychosis predicted higher subsequent inpatient mental healthcare use. Improving insight might benefit patients' course of illness as well as reduce mental health service use.
调查首发精神病患者的记录不良洞察力与心理健康和服务使用结果的关系。
我们开发了一种自然语言处理算法来确定不良或减弱洞察力的陈述,并在首发精神病患者队列中对其进行了测试。
英国伦敦南部和莫兹利国民保健服务信托的临床记录文本被使用。
我们应用该算法对参加早期干预服务的 2026 名首发精神病患者队列进行了特征描述。
在登记后 1 个月内记录的不良洞察力与(1)精神病住院的发生率,(2)被强制住院的几率,(3)精神科住院天数和(4)开处的不同抗精神病药物数量有关;在从 12 个月到 60 个月的不同随访期内,对结果进行了测量,调整了一系列社会人口统计学和临床协变量。
记录不良洞察力,存在于样本的 48.9%,与最年轻和最年长的年龄组、失业和精神分裂症(与双相情感障碍相比)呈正相关,与亚洲种族、已婚状态、拥有住房和记录的大麻使用呈负相关。在接下来的 12 个月中,它与所有四个结果的水平显著相关。当在 60 个月和 48 个月分别测量时,与住院发生率和抗精神病药物数量的关联仍然具有统计学意义。
首发精神病患者的记录不良洞察力预测了更高的后续住院精神保健使用。改善洞察力可能有益于患者的疾病进程,并减少精神卫生服务的使用。