[肠道对糖类的通透性测量：在乳糜泻和牛奶蛋白肠病诊断中的应用]

[Measurement of intestinal permeability to sugars: application in the diagnosis of celiac disease and cow's milk protein enteropathy].

作者信息

Dupont C, Barau E, Dehennin L, Molkhou P

机构信息

Fondation de Recherche en Hormonologie, Fresnes, France.

出版信息

Pathol Biol (Paris). 1987 Oct;35(8):1179-82.

PMID:3120136

Abstract

Intestinal permeability to macromolecules was studied by measuring differential urinary elimination of two orally ingested non-metabolizable sugars of different molecular size, mannitol and lactulose. In 25 control children, mannitol and lactulose urinary elimination were 16.30 +/- 5.77% and 0.33 +/- 0.10% of ingested dose, respectively, with a mean lactulose/mannitol (M/M) urinary ratio of 2.73 +/- 0.70%. In 7 celiac children, L/M ratio exhibited a significant rise: 8.53 +/- 2.54% (p less than 0.001). In 7 children with cow's milk sensitive enteropathy under exclusion diet, L/M ratio was normal in fasting condition: 2.63 +/- 1.28% and raised significantly during provocation test with milk: 7.22 +/- 3.88% (p less than 0.01). Intestinal permeability test is a reliable index of villous atrophy and cow's milk sensitive enteropathy.

摘要

通过测量两种口服摄入的不同分子大小的非代谢性糖（甘露醇和乳果糖）的尿排泄差异，研究了肠道对大分子的通透性。在25名对照儿童中，甘露醇和乳果糖的尿排泄量分别为摄入剂量的16.30±5.77%和0.33±0.10%，乳果糖/甘露醇（L/M）尿排泄比值平均为2.73±0.70%。在7名乳糜泻儿童中，L/M比值显著升高：8.53±2.54%（p<0.001）。在7名接受排除饮食的牛奶敏感肠病儿童中，禁食状态下L/M比值正常：2.63±1.28%，在牛奶激发试验期间显著升高：7.22±3.88%（p<0.01）。肠道通透性试验是绒毛萎缩和牛奶敏感肠病的可靠指标。