环状 RNA（circRNA）RAD23B 通过海绵吸附 miR-5095 促进食管癌细胞的增殖和侵袭。
CircRAD23B facilitates proliferation and invasion of esophageal cancer cells by sponging miR-5095.
机构信息
Department of Thoracic Surgery, Qingdao Chengyang District People's Hospital, NO.600 Changcheng Road, Chengyang District, Qingdao, 266109, China.
Department of Gynaecology, Qingdao Chengyang District People's Hospital, NO.600 Changcheng Road, Chengyang District, Qingdao, 266109, China.
出版信息
Biochem Biophys Res Commun. 2019 Aug 20;516(2):357-364. doi: 10.1016/j.bbrc.2019.06.044. Epub 2019 Jun 14.
Esophageal cancer is one of the most malignant tumors in digestive system, but the pathogenesis of esophageal cancer is still unclear. It has been verified that circular RNAs (circRNAs) play critical roles in development and progression of tumors. However, little research concentrates on the role of circRNAs in the pathogenesis of esophageal cancer. In the present study, we found that circular RNA-RAD23B (circRAD23B) was upregulated in specimens of patients with esophageal cancer. Further investigation revealed that circRAD23B promoted proliferation and invasion of esophageal cancer cells. Next, we identified microRNA-5095 (miR-5095) as a target of circRAD23B, and found that miR-5095 was negatively correlated to the expression of circRAD23B in esophageal cancer. In addition, circRAD23B facilitated expression of PARP2 and AKT2 by sponging miR-5095, which might underlie the growth of esophageal cancer. In summary, these data displayed the crucial role of circRAD23B/miR-5095 regulating PARP2 and AKT2 in esophageal cancer, and provided a novel mechanism in the pathogenesis of esophageal cancer.
食管癌是消化系统中最恶性的肿瘤之一，但食管癌的发病机制尚不清楚。已经证实环状 RNA（circRNAs）在肿瘤的发生和发展中起着关键作用。然而，很少有研究集中在 circRNAs 在食管癌发病机制中的作用。在本研究中，我们发现环状 RNA-RAD23B（circRAD23B）在食管癌患者的标本中上调。进一步的研究表明，circRAD23B 促进了食管癌细胞的增殖和侵袭。接下来，我们鉴定了 microRNA-5095（miR-5095）为 circRAD23B 的靶标，并发现 miR-5095 与食管癌中 circRAD23B 的表达呈负相关。此外，circRAD23B 通过海绵吸附 miR-5095 促进了 PARP2 和 AKT2 的表达，这可能是食管癌生长的基础。总之，这些数据显示了 circRAD23B/miR-5095 调节 PARP2 和 AKT2 在食管癌中的重要作用，并为食管癌的发病机制提供了新的机制。
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