一只来自澳大利亚动物园的苏门答腊虎（Panthera tigris sumatrae）患大型猫科动物白质脑脊髓病。

Large felid leucoencephalomyelopathy in a Sumatran tiger (Panthera tigris sumatrae) from an Australian zoo.

作者信息

Hanshaw D M, McLelland D J, Manavis J, Finnie J W

机构信息

Gribbles Veterinary Pathology, 33 Flemington Street, Glenside, South Australia, 5065, Australia.

Zoos South Australia, Adelaide, SA, Australia.

出版信息

Aust Vet J. 2019 Aug;97(8):277-282. doi: 10.1111/avj.12826. Epub 2019 Jun 17.

DOI:10.1111/avj.12826

PMID:31209862

Abstract

CASE REPORT

The clinicopathological features of a case consistent with large felid leucoencephalomyelopathy are described in a 19-year-old, zoo-based Sumatran tiger in which degenerative vertebral disease, renal insufficiency, diaphragmatic hernia and cataracts were comorbid. The principal presenting sign was ataxia, with concurrent deterioration of vertebral stiffness and vision loss. Histological features included marked destruction of the white matter, the formation of large, bizarre astrocytes and accumulation of numerous foamy macrophages (gitter cells). Immunohistochemical investigation of reactive astrocytes revealed several different cytoplasmic proteins.

CONCLUSION

This is the first reported case of large felid leucoencephalomyelopathy in Australia.

摘要

病例报告

描述了一只19岁圈养苏门答腊虎的临床病理特征，该病例符合大型猫科动物白质脑脊髓病，同时伴有退行性脊椎疾病、肾功能不全、膈疝和白内障。主要临床表现为共济失调，同时伴有脊椎僵硬加剧和视力丧失。组织学特征包括白质的显著破坏、大型怪异星形胶质细胞的形成以及大量泡沫状巨噬细胞（格子细胞）的积聚。对反应性星形胶质细胞的免疫组织化学研究揭示了几种不同的细胞质蛋白。