Ulukan Mustafa Ozer, Ugurlucan Murat, Unal Orcun, Yılmaz Muhammet Fatih, Kasifoglu Nilgun, Sevin M Behcet
Department of Cardiovascular Surgery, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey.
Department of Cardiovascular Surgery, Medical Faculty, Istanbul University, Istanbul, Turkey.
Arch Med Sci Atheroscler Dis. 2019 May 28;4:e119-e125. doi: 10.5114/amsad.2019.85426. eCollection 2019.
Heart-type fatty acid-binding protein (H-FABP) is a novel indicator of myocardial damage. The aim of the study was to compare the levels of H-FABP in off-pump and on-pump coronary artery bypass grafting (CABG).
Thirty non-randomised 30 patients who underwent CABG between January 2009 and January 2010 were enrolled in the study. Patients were divided into two equal size ( = 15) groups as group A (off-pump CABG group) and group B (on-pump CABG group). Three arterial blood samples were obtained for H-FABP after sternotomy (H-FABP 1), after the last distal anastomosis in group A and immediately after the cross clamp was removed from the aorta in group B (H-FABP 2) and 24 h after the operation (H-FABP 3). Renal and liver functions and circulating fatty acid binding protein (FABP) levels were also assessed in blood samples obtained 24 h before and 1 h after the operation.
At all three assessment points patients in group B had significantly higher H-FABP values when compared with group A. Preoperative renal and liver functions were similar in both groups and they did not differ significantly in group A and group B when preoperative and postoperative values were compared. In both groups circulating FABP levels increased in the postoperative period, and the increase was more pronounced in the on-pump CABG group.
On-pump surgery resulted in higher levels of H-FABP as an ischaemic marker in patients receiving coronary artery bypass surgery.
心脏型脂肪酸结合蛋白（H-FABP）是心肌损伤的一种新型指标。本研究的目的是比较非体外循环和体外循环冠状动脉旁路移植术（CABG）中H-FABP的水平。
选取2009年1月至2010年1月期间接受CABG的30例非随机患者纳入研究。患者被分为两组，每组15例，A组（非体外循环CABG组）和B组（体外循环CABG组）。胸骨切开术后（H-FABP 1）、A组最后一个远端吻合术后以及B组主动脉阻断钳移除后立即（H-FABP 2）和术后24小时（H-FABP 3）采集三份动脉血样本检测H-FABP。在术前24小时和术后1小时采集的血样中还评估了肾功能、肝功能和循环脂肪酸结合蛋白（FABP）水平。
在所有三个评估点，B组患者的H-FABP值均显著高于A组。两组术前肾功能和肝功能相似，A组和B组术前和术后值比较差异无统计学意义。两组术后循环FABP水平均升高，且在体外循环CABG组升高更为明显。
在接受冠状动脉旁路移植手术的患者中，体外循环手术导致作为缺血标志物的H-FABP水平更高。
